Telomere profiles and tumor-associated macrophages with different immune signatures affect prognosis in glioblastoma

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Noelyn A HungTania L Slatter

Abstract

Telomere maintenance is a hallmark of cancer and likely to be targeted in future treatments. In glioblastoma established methods of identifying telomerase and alternative lengthening of telomeres leave a significant proportion of tumors with no defined telomere maintenance mechanism. This study investigated the composition of these tumors using RNA-Seq. Glioblastomas with an indeterminate telomere maintenance mechanism had an increased immune signature compared with alternative lengthening of telomeres and telomerase-positive tumors. Immunohistochemistry for CD163 confirmed that the majority (80%) of tumors with an indeterminate telomere maintenance mechanism had a high presence of tumor-associated macrophages. The RNA-Seq and immunostaining data separated tumors with no defined telomere maintenance mechanism into three subgroups: alternative lengthening of telomeres like tumors with a high presence of tumor-associated macrophages and telomerase like tumors with a high presence of tumor-associated macrophages. The third subgroup had no increase in tumor-associated macrophages and may represent a distinct category. The presence of tumor-associated macrophages conferred a worse prognosis with reduced patient survival times (alter...Continue Reading

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May 13, 2018·Genes·Tiago Bordeira GasparJoão Vinagre
Dec 16, 2017·Scientific Reports·Anna GieryngBozena Kaminska
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