Telomere shortening in mucosa surrounding the tumor: biosensor of field cancerization and prognostic marker of mucosal failure in head and neck squamous cell carcinoma

Oral Oncology
Paolo Boscolo-RizzoAnita De Rossi

Abstract

The aim of the present study was to investigate the pattern of telomere length and telomerase expression in cancer tissues and the surrounding mucosa (SM), as markers of field cancerization and clinical outcome in patients successfully treated for with head and neck squamous cell carcinoma (HNSCC). This investigation was a prospective cohort study. Telomere length and levels of telomerase reverse transcriptase (TERT) transcripts were quantified by real-time PCR in cancer tissues and SM from 139 and 90 patients with HNSCC, respectively. No correlation was found between age and telomere length in SM. Patients with short telomeres in SM had a higher risk of mucosal failure (adjusted HR=4.29). Patients with high TERT levels in cancer tissues had a higher risk of regional failure (HR=2.88), distant failure (HR=7.27), worse disease-specific survival (HR for related death=2.62) but not mucosal failure. High-risk patients having both short telomeres in SM and high levels of TERT in cancer showed a significantly lower overall survival (HR=2.46). Overall these findings suggest that telomere shortening in SM is a marker of field cancerization and may precede reactivation of TERT. Short telomeres in SM are strongly prognostic of mucosal fa...Continue Reading

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Citations

Aug 6, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·G TirelliM Piovesana
Aug 10, 2016·Cancer Metastasis Reviews·Paolo Boscolo-RizzoAnita De Rossi
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Sep 7, 2019·Pathology Oncology Research : POR·Lizbeth Raju KShwetha Nambiar
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Sep 18, 2020·International Journal of Molecular Sciences·Davide B GissiLucio Montebugnoli
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Feb 11, 2020·Taiwanese Journal of Obstetrics & Gynecology·Anna PańczyszynGrzegorz Głąb

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