Telomere shortening velocity of patients administered with hypnotics is accelerated in a gender-differential manner.

Canadian Journal of Physiology and Pharmacology
Toyoki MaedaNaoki Makino

Abstract

The telomere length and its distribution were compared between patients administered with and without hypnotics to see if regular administration of hypnotics is associated with their aging-related somatic telomere shortening. Male patients presented significant shortening of telomere length of circulating leukocytes in association with age (-41.9 bp/year, p = 0.045) in contrast with controls (-18.3 kb/year, p = 0.155). On the other hand, female patients presented no significant shortening of telomere length with aging (-16.4 bp/year, p = 0.372) in contrast with controls (-55.9 bp/year, p = 0.00005). These results suggested that regular administration of hypnotics is associated with aging progression in a gender-related manner. The administration of hypnotics could be an indicator as the somatic aging status and for the screening of background lifestyle-associated diseases promoting biological aging.

References

Nov 19, 1977·British Medical Journal·J Thomson, I Oswald
Apr 18, 1991·Nature·E H Blackburn
Apr 24, 1971·British Medical Journal·D Williams
Jun 3, 1998·American Journal of Obstetrics and Gynecology·P Polo-KantolaO Polo
Jun 14, 2000·Seminars in Reproductive Endocrinology·K E Moe
Mar 27, 2001·Family Practice·L W MaartensV J Pop
Jan 17, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Masayuki OgamiMakiko Ueda
Dec 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Elissa S EpelRichard M Cawthon
Aug 12, 2005·Journal of Hypertension·Toshio ImanishiIchiro Nishio
Aug 23, 2005·Lancet·A M ValdesT D Spector
Jun 28, 2007·Molecular and Cellular Biochemistry·Jing Zhi GuanNaoki Makino
Nov 8, 2007·Annals of the New York Academy of Sciences·Sharyn BayneJun-Ping Liu
Jan 29, 2008·Chemical Society Reviews·Chun-Hui Clayton ZhouG Q Max Lu
Apr 9, 2008·Physiological Reviews·Geraldine Aubert, Peter M Lansdorp
Oct 14, 2010·Journal of the American Society of Hypertension : JASH·Kazuo EguchiKazuomi Kario
Nov 19, 2013·Current Cardiovascular Risk Reports·John H KingsburyKaren M Emmons
Dec 31, 2015·Sleep·Judith E CarrollMichael R Irwin

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Citations

May 18, 2021·Homeopathy : the Journal of the Faculty of Homeopathy·Marcus Zulian Teixeira

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