Telomeres and telomerase in prostatic intraepithelial neoplasia and prostate cancer biology

Urologic Oncology
Alan K Meeker

Abstract

Telomeres are terminal, repeated deoxyribonucleic acid (DNA) sequences that stabilize and protect the ends of the chromosomes. Mounting evidence indicates that by initiating chromosomal instability, short dysfunctional telomeres may be involved in prostate carcinogenesis. Although the exact cause of the telomere shortening observed in prostate cancer remains a mystery, telomere loss is known to occur during cell division and oxidative DNA damage, 2 byproducts of chronic inflammation, which is a common histologic finding in the prostate. In addition to prostate cancer causation, telomeres may also play a role in disease progression, and there are indications that tumor telomere content may prove useful as a prognostic marker. Once established, prostate cancer cells almost invariably activate the telomeric DNA polymerase enzyme telomerase, the detection of which may prove useful for diagnostic purposes. Interestingly, telomerase activity is suppressed in prostate cancer cells after androgen withdrawal, raising the possibility that androgen ablative therapies may re-instigate telomere loss, and consequent genetic instability, in surviving cancer cells, thus contributing to the emergence of an androgen-independent, lethal phenotype...Continue Reading

References

Jun 20, 1992·Journal of Molecular Biology·M Z LevyC B Harley
Oct 1, 1991·Trends in Biochemical Sciences·E H Blackburn
Jan 1, 1991·Mutation Research·J LindseyH J Cooke
May 31, 1990·Nature·C B HarleyC W Greider
Aug 30, 1990·Nature·N D HastieR C Allshire
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J MeyneR K Moyzis
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R K MoyzisJ R Wu
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·P A KrukV A Bohr
Feb 14, 1997·Science·L HarringtonM O Robinson
Mar 1, 1997·The Journal of Urology·Y LinY Kubota
Apr 24, 1997·Nature·K W Kinzler, B Vogelstein
Apr 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J W Shay, S Bacchetti
Aug 1, 1997·British Journal of Urology·D K ScatesP L Carmichael
Aug 1, 1997·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·B V KallakuryJ S Ross
Dec 31, 1997·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J LübbeG Burg
Jul 17, 1998·The American Journal of Pathology·N N NupponenT Visakorpi
Dec 22, 1998·Molecular and Cellular Biology·J R MitchellK Collins
Jan 1, 1999·Nature·C LengauerB Vogelstein
Apr 10, 1999·Genes & Development·S E HoltM A White
Aug 10, 1999·Nature·W C HahnR A Weinberg
Dec 10, 1999·International Journal of Cancer. Journal International Du Cancer·A W HsingS S Devesa
Feb 3, 2000·Free Radical Biology & Medicine·T von ZglinickiN Sitte
Feb 19, 2000·Current Opinion in Genetics & Development·S E Artandi, R A DePinho
Mar 11, 2000·Molecular Biology of the Cell·S LeC W Greider
Feb 7, 2001·International Journal of Cancer. Journal International Du Cancer·A LatilI Biàche
Apr 12, 2000·European Journal of Clinical Investigation·L F WymengaH J Mensink
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·D GisselssonN Mandahl

❮ Previous
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Citations

Aug 2, 2011·Annual Review of Cell and Developmental Biology·Teresa Davoli, Titia de Lange
Mar 27, 2007·Nature Reviews. Cancer·Angelo M De MarzoWilliam G Nelson
Aug 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Masood A ShammasRaj K Goyal
Sep 14, 2010·Asian Journal of Andrology·Jeremy D Henson
Nov 26, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Masood A Shammas
Oct 5, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Jagannath PalMasood A Shammas
Feb 28, 2007·Neoplasia : an International Journal for Oncology Research·Anthony Michael JoshuaJeremy Andrew Squire
Feb 9, 2008·The Journal of Molecular Diagnostics : JMD·Georg Feldmann, Anirban Maitra
Jan 2, 2008·Biochimica Et Biophysica Acta·A M JoshuaJ A Squire
Aug 6, 2010·The Prostate·Christopher M HeaphyMarco Bisoffi
May 1, 2013·Genes, Chromosomes & Cancer·Andrew J PellattMartha L Slattery
Mar 1, 2011·Journal of Cellular and Molecular Medicine·Christopher M Heaphy, Alan K Meeker
Apr 17, 2012·Genes, Chromosomes & Cancer·Rasa SabaliauskaiteJuozas R Lazutka
Nov 29, 2013·The Prostate·Lauren M HurwitzAlan K Meeker
Aug 5, 2015·Prostate Cancer and Prostatic Diseases·C GuD Ye
May 20, 2015·Human Genetics·Jennifer H BarrettKaren A Pooley
Jan 9, 2010·Expert Opinion on Therapeutic Targets·Kerrilyn R DienerJohn D Hayball
Jan 4, 2012·Histopathology·David G Bostwick, Liang Cheng
Jul 22, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Verena Sailer, Glen Kristiansen
May 9, 2012·Asian Journal of Andrology·Sahn-Ho KimG Prem Veer Reddy
Nov 15, 2007·Cytogenetic and Genome Research·O Calcagnile, D Gisselsson
Jan 11, 2019·International Journal of Molecular Sciences·Hueng-Chuen FanHorng-Jyh Harn
Sep 8, 2020·BJU International·Conor M DevlinNorman J Maitland

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