Telomeres: structures in need of unwinding.

FEBS Letters
Katrin PaeschkeVirginia A Zakian

Abstract

Telomeres protect the ends of eukaryotic chromosomes from being recognized and processed as double strand breaks. In most organisms, telomeric DNA is highly repetitive with a high GC-content. Moreover, the G residues are concentrated in the strand running 3'-5' from the end of the chromosome towards its center. This G-rich strand is extended to form a 3' single-stranded tail that can form unusual secondary structures such as T-loops and G-quadruplex DNA. Both the duplex repeats and the single-stranded G-tail are assembled into stable protein-DNA complexes. The unique architecture, high GC content, and multi-protein association create particularly stable protein-DNA complexes that are a challenge for replication, recombination, and transcription. Helicases utilize the energy of nucleotide hydrolysis to unwind base paired nucleic acids and, in some cases, to displace proteins from them. The telomeric functions of helicases from the RecQ, Pifl, FANCJ, and DNA2 families are reviewed in this article. We summarize data showing that perturbation of their telomere activities can lead to telomere dysfunction and genome instability and in some cases human disease.

References

Apr 25, 1991·Nature·A M ZahlerD M Prescott
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R J Wellinger, V A Zakian
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·F Foury, J Kolodynski
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·M E Budd, J L Campbell
Jan 1, 1993·Cold Spring Harbor Symposia on Quantitative Biology·R J WellingerV A Zakian
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·L L SandellV A Zakian
May 3, 1996·Cell·R J WellingerV A Zakian
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·I Dionne, R J Wellinger
Apr 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R J Wellinger, D Sen
Dec 16, 1997·Trends in Biochemical Sciences·V MorozovP Bork
Feb 26, 1998·Cell·B van SteenselT de Lange
May 30, 1998·Genes & Development·F G Harmon, S C Kowalczykowski
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·L ZhuR J Hodes
Apr 13, 1999·Nucleic Acids Research·H SunN Maizels
May 25, 1999·Cell·J D GriffithT de Lange
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·K G Murti, D M Prescott
Dec 14, 1999·Molecular Microbiology·M C Hall, S W Matson
Jan 15, 2000·Science·J W Shay, W E Wright
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·C BaiC T Caskey

❮ Previous
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Citations

Apr 19, 2011·Chromosoma·Brankica MravinacMiroslav Plohl
Apr 17, 2012·The Journal of Physical Chemistry. B·Mohammad H QureshiHamza Balci
Oct 4, 2012·Nature Reviews. Genetics·Matthew L BochmanVirginia A Zakian
Jun 17, 2011·The Journal of Biological Chemistry·Amadou BahRaymund J Wellinger
Jan 31, 2012·Nucleic Acids Research·Yuliang Wu, Robert M Brosh
Jun 5, 2013·Cold Spring Harbor Perspectives in Biology·Christopher J WebbVirginia A Zakian
Apr 4, 2013·BMC Molecular Biology·Nicholas W AshtonDerek J Richard
Oct 29, 2013·Nucleic Acids Research·Alexander HendersonPeter M Lansdorp
Aug 14, 2012·Journal of Nucleic Acids·Yuliang Wu
Sep 26, 2014·Nature Communications·Julien HardyMarie-Noëlle Simon
Oct 12, 2013·Genes & Development·Liuh-Yow ChenJoachim Lingner
Feb 14, 2013·Molecular BioSystems·Aradhita BaralShantanu Chowdhury
Feb 4, 2011·Expert Opinion on Therapeutic Targets·Marco FoliniNadia Zaffaroni
Aug 27, 2013·Expert Opinion on Therapeutic Patents·Yiyong YanLianquan Gu
Jul 23, 2014·Critical Reviews in Biochemistry and Molecular Biology·Guido KeijzersVilhelm A Bohr
Dec 4, 2014·European Journal of Medicinal Chemistry·Yun-Xia XiongJia-Heng Tan
Sep 10, 2015·Nucleic Acids Research·Daniela Rhodes, Hans J Lipps
May 28, 2013·Biophysical Journal·Sujay RayHamza Balci
Oct 8, 2013·Journal of Molecular Biology·Anne-Sophie BoyerJean-Sébastien Hoffmann
May 20, 2015·Nature Communications·Boris BartholdyEric E Bouhassira
Jun 14, 2013·Cell Cycle·Margit DlaskaOliver E Bechter
Mar 5, 2013·American Journal of Human Genetics·Amanda J WalneInderjeet Dokal
May 1, 2016·Nucleic Acids Research·Jinhu YinYie Liu
May 29, 2016·DNA Repair·Carly L Geronimo, Virginia A Zakian
Jul 5, 2016·Genes·Sanjay Kumar BhartiRobert M Brosh
Sep 21, 2016·Genes·Deanna Elise MacNeilChantal Autexier
Oct 1, 2016·PLoS Genetics·Anukana BhattacharjeeCarolyn M Price
Mar 19, 2016·PLoS Genetics·Mariana C GadaletaEishi Noguchi
Jun 29, 2017·Chemical Research in Toxicology·Razan CharifSophie Bombard
Jul 25, 2018·Genes·Magdalena A BudzinskaThomas Tu
Oct 28, 2015·Chemistry : a European Journal·Martin Gasiorek, Hans-Jörg Schneider
Mar 17, 2019·Cells·Nicole BettinEmilio Cusanelli
Aug 13, 2013·The Journal of Biological Chemistry·Sanjay Kumar BhartiRobert M Brosh
Jun 8, 2017·Bioscience Reports·Jing YouXu-Guang Xi
Oct 10, 2014·Beilstein Journal of Organic Chemistry·Christine Beuck, Elmar Weinhold
Sep 18, 2020·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Alejandro D Bolzán
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tracy M Bryan
Apr 13, 2018·Nucleic Acids Research·Marko TrajkovskiNaoki Sugimoto
Feb 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·In Pyo HwangLauréline Roger

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