Telomeric restriction analysis of vascular smooth muscle cells following balloon angioplasty in rabbits.

Journal of Physiology and Biochemistry
Gonen Ozsarlak-SozerZ Topcu

Abstract

Intimal hyperplasia due to smooth muscle cell proliferation and migration has been reported to be responsible for the pathogenesis of atherosclerosis and restenosis, manifested following balloon angioplasty. In this study, we employed the balloon angioplasty model to study telomere length regulation in proliferating vascular smooth muscle cells. Our results showed that balloon angioplasty in iliac arteries resulted in intimal hyperplasia due to proliferation of the smooth muscle cells and small size telomeric restrictional fragments were evident in injured arteries.

References

Mar 12, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·L R BoninS C Conroy
Nov 2, 2002·Nature Medicine·Victor J DzauDaniel G Sedding
Apr 12, 2005·Cardiovascular Research·María Dolores Edo, Vicente Andrés

❮ Previous
Next ❯

Citations

Oct 7, 2010·Journal of Physiology and Biochemistry·Gonen Ozsarlak-SozerZeki Topcu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.