TeloPIN: a database of telomeric proteins interaction network in mammalian cells

Database : the Journal of Biological Databases and Curation
Zhenhua LuoYuanyan Xiong

Abstract

Interaction network surrounding telomeres has been intensively studied during the past two decades. However, no specific resource by integrating telomere interaction information data is currently available. To facilitate the understanding of the molecular interaction network by which telomeres are associated with biological process and diseases, we have developed TeloPIN (Telomeric Proteins Interaction Network) database (http://songyanglab.sysu.edu.cn/telopin/), a novel database that points to provide comprehensive information on protein-protein, protein-DNA and protein-RNA interaction of telomeres. TeloPIN database contains four types of interaction data, including (i) protein--protein interaction (PPI) data, (ii) telomeric proteins ChIP-seq data, (iii) telomere-associated proteins data and (iv) telomeric repeat-containing RNAs (TERRA)-interacting proteins data. By analyzing these four types of interaction data, we found that 358 and 199 proteins have more than one type of interaction information in human and mouse cells, respectively. We also developed table browser and TeloChIP genome browser to help researchers with better integrated visualization of interaction data from different studies. The current release of TeloPIN da...Continue Reading

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Citations

Jan 10, 2016·Nucleic Acids Research·Guillaume GaullierMarie-Hélène Le Du
Aug 30, 2017·Antioxidants & Redox Signaling·Shizuka Uchida, Roberto Bolli
May 18, 2016·Oncotarget·Natalia Gomez-EscobarRamsay J McFarlane
Jun 24, 2018·Scientific Reports·Dharm Skandh JainRaviprasad Aduri
May 20, 2018·BMC Genetics·Delia M BraunKarsten Rippe

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Methods Mentioned

BETA
immunoprecipitation
ChIP-seq
two-hybrid
Fluorescence
pull-down
ChIP
Protein ChIP

Software Mentioned

Bowtie
TeloChIP ChIP table browser
TeloChIP Browser
TeloPIN
PICh
Table Browser
MACS
TeloPINtable
TeloChIPto
MySQL

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