TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer

Cancer Medicine
Satoshi FujiiAtsushi Ochiai

Abstract

The cancer stroma, including cancer-associated fibroblasts (CAFs), is known to contribute to cancer cell progression and metastasis, suggesting that functional proteins expressed specifically in CAFs might be candidate molecular targets for cancer treatment. The purpose of the present study was to explore the possibility of using TEM1 (tumor endothelial marker 1), which is known to be expressed in several types of mesenchymal cells, as a molecular target by examining the impact of TEM1 expression on clinicopathological factors in gastric cancer patients. A total of 945 consecutive patients with gastric cancer who underwent surgery at the National Cancer Center Hospital East between January 2003 and July 2007 were examined using a tissue microarray approach. TEM1 expression in CAFs or vessel-associated cells was determined using immunohistochemical staining. Three items (CAF-TEM1-positivity, CAF-TEM1-intensity, and vessel-TEM1-intensity) were then examined to determine the correlations between the TEM1 expression status and the recurrence-free survival (RFS), overall survival (OS), cancer-related survival (COS), and other clinicopathological factors. Significant correlations between CAF-TEM1-positivity or CAF-TEM1-intensity and ...Continue Reading

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Citations

Nov 8, 2017·International Journal of Molecular Sciences·Ana CavacoJohannes A Eble
Sep 8, 2020·Cancer Metastasis Reviews·Rachel E SextonAsfar S Azmi
Nov 20, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Dakeun LeeHoon Hur
Jan 30, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Francesco CiconeJohn O Prior
May 19, 2019·Cell Communication and Signaling : CCS·Zhanhuai WangWei Yu
Jun 25, 2020·Advanced Drug Delivery Reviews·Patrick M GlassmanVladimir R Muzykantov

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