Temozolomide as salvage treatment for recurrent intracranial ependymomas of the adult: a retrospective study

Neuro-oncology
Roberta RudàRiccardo Soffietti

Abstract

Few data are available on temozolomide (TMZ) in ependymomas.We investigated the response, survival, and correlation with MGMT promoter methylation in a cohort of patients with adult intracranial ependymoma receiving TMZ as salvage therapy after failure of surgery and radiotherapy. We retrieved clinical information from the institutional database and follow-up visits, and response to TMZ on MRI was evaluated according to the MacDonald criteria. Eighteen patients (median age, 42 y), with either WHO grade III (10) or grade II (8) ependymoma were evaluable. Tumor location at diagnosis was supratentorial in 11 patients and infratentorial in 7. Progression before TMZ was local in 11 patients, local and spinal in 6 patients, and spinal only in one patient. A median of 8 cycles of TMZ (1-24) was administered. Response to TMZ consisted of complete response (CR) in one (5%) patient, partial response (PR) in 3 (17%) patients, stable disease (SD) in 7 (39%) patients, and progressive disease (PD) in 7 (39%) patients. Maximum response occurred after 3, 10, 14, and 15 cycles, respectively, with neurological improvement in 2 patients. All 4 responding patients were chemotherapy naïve. Both anaplastic (2) and grade II (2) tumors responded. Medi...Continue Reading

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Citations

Mar 30, 2016·Neuro-oncology·Jing WuMark R Gilbert
Dec 2, 2017·Neuro-oncology·Roberta RudàElizabeth Cohen-Jonathan Moyal
Dec 23, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Yasushi FujiwaraNobuo Adachi
Dec 9, 2017·Journal of Neurosurgery. Spine·Theresa KraetzigIlya Laufer
Mar 6, 2019·Current Oncology Reports·Jason ChuaDenise Leung
Jul 31, 2019·Current Oncology Reports·Sebastian M Toescu, Kristian Aquilina
Nov 29, 2015·Journal of Neuro-oncology·Alessia PellerinoRoberta Rudà
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Jan 29, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Francesco BrunoRoberta Rudà
Jul 18, 2020·Frontiers in Oncology·Enrico FranceschiUNKNOWN EURACAN Domain 10
Feb 3, 2021·The Neuroradiology Journal·Marco VarrassiCarlo Masciocchi

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