Temozolomide in advanced and recurrent uterine leiomyosarcoma and correlation with o6-methylguanine DNA methyltransferase expression: a case series

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
J Stuart FerrissAmir A Jazaeri

Abstract

Our objective was to retrospectively review temozolomide in advanced and recurrent uterine leiomyosarcoma and to determine if tumor O-methylguanine DNA methyltransferase (MGMT) expression correlated with clinical response. All patients with advanced or recurrent uterine leiomyosarcoma who received temozolomide during treatment were retrospectively identified. Relevant clinical and pathologic data were collected and compared. O-Methylguanine DNA methyltransferase expression was assessed by immunohistochemistry and scored by a gynecologic pathologist blinded to clinical outcomes. From 1999 to 2008, 9 cases of leiomyosarcoma were diagnosed; 6 patients received temozolomide. Median follow-up was 54 months (range, 4-114 months). There was 1 patient with complete response, 1 durable partial response (27+ months), 3 stable disease (range, 3-10 months), and 1 progressive disease. Overall, 5 out of 6 patients derived clinical benefit. The patient with a complete response recurred 18 months after her last cycle. Median progression free interval was 15.4 months (95% confidence interval, 9.4-21.4). Two patients died of disease. Temozolomide was well tolerated with no dose-limiting toxicities, and no dose adjustments were required in 64 pre...Continue Reading

References

Sep 1, 1992·Carcinogenesis·J M ChenM Ikenaga
Jul 27, 1999·Gynecologic Oncology·K MayerhoferC Kainz
Jun 28, 2002·British Journal of Cancer·M J ClemonsG P Margison
Oct 8, 2003·Gynecologic Oncology·Mario M LeitaoDennis S Chi
Mar 30, 2004·Gynecologic Oncology·Sandra E BrooksClaudia R Baquet
May 27, 2005·Gynecologic Oncology·Sibyl Anderson, Carol Aghajanian
Jul 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ian F PollackJonathan L Finlay
Apr 17, 2007·Gynecologic Oncology·Robert L GiuntoliBobbie S Gostout
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Apr 2, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N S ReedUNKNOWN European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group
Sep 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Monika E HegiMark R Gilbert
Nov 1, 2008·Gynecologic Oncology·B J RimelPaul J Goodfellow
Jan 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew H KulkeMark S Redston

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Citations

Oct 11, 2016·Sarcoma·Heather MillerMatthew L Anderson
Nov 25, 2014·Expert Opinion on Pharmacotherapy·Angiolo Gadducci, Maria Elena Guerrieri
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Eriksson
Mar 30, 2019·Autism : the International Journal of Research and Practice·Jamal M Al KhateebMuna S Al Hadidi
May 21, 2014·Current Opinion in Oncology·David M HymanMartee L Hensley
May 21, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Elena García-MartínezAntonio González-Martín
Jan 1, 2012·American Society of Clinical Oncology Educational Book·Martee L Hensley
Sep 29, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marije E WeidemaUNKNOWN PALGA Group

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