Temozolomide therapy for aggressive pituitary tumours - current understanding and future perspectives.

Reviews in Endocrine & Metabolic Disorders
Pia BurmanAnn McCormack

Abstract

The use of temozolomide (TMZ) for the management of aggressive pituitary tumours (APT) has revolutionised clinical practice in this field with significantly improved clinical outcomes and long-term survival. Its use is now well established however a large number of patients do not respond to treatment and recurrence after cessation of TMZ is common. A number of challenges remain for clinicians such as appropriate patient selection, treatment duration and the role of combination therapy. This review will examine the use of TMZ to treat APT including mechanism of action, treatment regimen and duration; biomarkers predicting response to treatment and patient selection; and current evidence for administration of TMZ in combination with other agents.

References

Dec 16, 1998·The Journal of Clinical Endocrinology and Metabolism·G A KaltsasG M Besser
Mar 27, 2001·Journal of Cellular Physiology·G Aquilina, M Bignami
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Rita E LandmanSharon L Wardlaw
Jul 29, 2004·DNA Repair·Lovorka StojicJosef Jiricny
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Mar 11, 2005·The New England Journal of Medicine·Monika E HegiRoger Stupp
Jan 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lili Liu, Stanton L Gerson
May 16, 2006·Cancer Treatment Reviews·Cara A RabikM Eileen Dolan
Jun 6, 2006·The Lancet Oncology·Stephen LimAnthony P Heaney
Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Arnab ChakravartiJay S Loeffler
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel P CahillDavid N Louis
May 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sara EkebladBritt Skogseid
Sep 28, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Francesco MarchesiLiana De Vecchis
Oct 11, 2007·Acta Neuropathologica·Kalman KovacsLuis C Penagos
Jul 4, 2008·Nature Reviews. Cancer·Lee M Ellis, Daniel J Hicklin
Sep 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bart NeynsPouratian Nader
Jan 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew H KulkeMark S Redston
Jul 9, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephen YipDavid N Louis
Aug 12, 2009·Southern Medical Journal·Benjamin J GeorgeThomas J Richard
Jul 28, 2010·The Journal of Clinical Endocrinology and Metabolism·Gérald RaverotThierry Brue
Aug 27, 2010·Pituitary·Queenie LauRicardo Lloyd
Feb 12, 2011·Journal of Neuro-oncology·Fateme SalehiRicardo V Lloyd
Apr 19, 2011·European Journal of Clinical Investigation·Ann I McCormackAshley B Grossman
Nov 30, 2011·Current Molecular Pharmacology·Jihong ZhangTracey D Bradshaw
Jan 13, 2012·Nature Reviews. Cancer·Dragony FuLeona D Samson
Mar 1, 2012·Clinical Endocrinology·B C WhitelawS J B Aylwin
Apr 24, 2012·Annales d'endocrinologie·Melanie PhilipponFrédéric Castinetti
Mar 23, 2013·Neuro-oncology·Hiroyuki MomotaSoichiro Shibui
Oct 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark R GilbertMinesh P Mehta
Nov 23, 2013·Nature Reviews. Cancer·Hira Lal Goel, Arthur M Mercurio
May 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Marco MendolaSabrina Corbetta
Aug 1, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephanie A NguyenSamuel Weiss
Nov 28, 2014·Nature·Matthew M GubinRobert D Schreiber
Feb 7, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael WellerUNKNOWN DIRECTOR Study Group
Jun 2, 2015·The New England Journal of Medicine·Dung T LeLuis A Diaz

❮ Previous
Next ❯

Citations

Oct 28, 2020·The Journal of Clinical Endocrinology and Metabolism·Olivera Casar-BorotaPia Burman
Mar 11, 2021·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Stephan Petersenn
May 22, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sylvia L AsaUNKNOWN Attendees of the 15th Meeting of the International Pituitary Pathology Club, Istanbul October 2019

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Tomokazu Aoki
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Mustafa KhasrawHelen Wheeler
© 2021 Meta ULC. All rights reserved