Temozolomide treatment of a malignant pheochromocytoma and an unresectable MAX-related paraganglioma

Anti-cancer Drugs
Alfonso M FerraraStefania Zovato

Abstract

Pheochromocytomas (PCCs) and paragangliomas (PGLs) are neuroendocrine tumors with a strong genetic background. The mainstay of treatment for PCC/PGLs is surgery. However, for unresectable lesions, no curative treatment is currently available. Temozolomide (TMZ) has been shown to determine radiological and biochemical response in malignant PCC/PGLs. We report two cases of PCC/PGLs treated with TMZ. Case 1 is a 51-year-old man with local and distant recurrence (liver and bone metastases) of right adrenal PCC. Case 2 is a 54-year-old woman with a PCC/PGL syndrome caused by a mutation in MAX gene (c.171+1G>A), operated on for bilateral adrenal PCC and presenting with a large unresectable abdominal PGL. Both patients presented hypertension due to catecholamine hypersecretion. TMZ determined radiological response according to RECIST criteria, reduction of urinary catecholamine levels, and controlled hypertension in both patients. Furthermore, the current study demonstrates, for the first time, that MAX-related PGLs are responsive to TMZ.

References

Jul 24, 2001·Medical and Pediatric Oncology·Y Tsuchida, P Therasse
Mar 11, 2005·The New England Journal of Medicine·Monika E HegiRoger Stupp
Jan 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew H KulkeCharles S Fuchs
May 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sara EkebladBritt Skogseid
Jun 19, 2009·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E L BravoI Gill
Mar 17, 2011·International Journal of Radiation Biology·Maria De SalvoBarbara Bucci
Mar 21, 2012·European Journal of Endocrinology·Cécile NozièresCatherine Lombard-Bohas
Feb 26, 2013·The Journal of Clinical Endocrinology and Metabolism·Montserrat Ayala-RamirezCamilo Jimenez
Jan 21, 2014·Nature Reviews. Cancer·Patricia L M Dahia
Apr 23, 2014·International Journal of Cancer. Journal International Du Cancer·Julien HadouxEric Baudin
Jun 4, 2014·European Journal of Endocrinology·Eric BaudinCamilo Jimenez
Nov 29, 2015·Hematology/oncology Clinics of North America·Lauren Fishbein

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Citations

Mar 21, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Oksana Hamidi
Aug 12, 2019·Best Practice & Research. Clinical Endocrinology & Metabolism·Maurizio IacoboneFrancesca Torresan
Jan 20, 2021·The Journal of Clinical Endocrinology and Metabolism·Dan GranbergHenrik Falhammar
Dec 29, 2020·The Journal of Clinical Endocrinology and Metabolism·Amanda J SeabrookEmma L Duncan

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