Temperature and magnetism bi-responsive molecularly imprinted polymers: Preparation, adsorption mechanism and properties as drug delivery system for sustained release of 5-fluorouracil

Materials Science & Engineering. C, Materials for Biological Applications
Longfei LiYongkang Chen

Abstract

Temperature and magnetism bi-responsive molecularly imprinted polymers (TMMIPs) based on Fe3O4-encapsulating carbon nanospheres were prepared by free radical polymerization, and applied to selective adsorption and controlled release of 5-fluorouracil (5-FU) from an aqueous solution. Characterization results show that the as-synthesized TMMIPs have an average diameter of about 150 nm with a typical core-shell structure, and the thickness of the coating layer is approximately 50 nm. TMMIPs also displayed obvious magnetic properties and thermo-sensitivity. The adsorption results show that the prepared TMMIPs exhibit good adsorption capacity (up to 96.53 mg/g at 25 °C) and recognition towards 5-FU. The studies on 5-FU loading and release in vitro suggest that the release rate increases with increasing temperature. Meanwhile, adsorption mechanisms were explored by using a computational analysis to simulate the imprinted site towards 5-FU. The interaction energy between the imprinted site and 5-FU is -112.24 kJ/mol, originating from a hydrogen bond, Van der Waals forces and a hydrophobic interaction between functional groups located on 5-FU and a NIPAM monomer. The electrostatic potential charges and population analysis results sugge...Continue Reading

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Citations

Aug 28, 2016·Analytica Chimica Acta·Todd CowenSergey Piletsky
Jan 21, 2017·Journal of Biomaterials Science. Polymer Edition·Pınar ÖncelAdil Denizli
May 10, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Piotr Luliński
Jan 3, 2019·Critical Reviews in Analytical Chemistry·Shabi Abbas Zaidi
Feb 19, 2019·Journal of Biomaterials Science. Polymer Edition·Emel TamahkarAdil Denizli
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Mar 16, 2019·Sensors·Yeşeren SaylanAdil Denizli
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Aug 18, 2020·International Journal of Nanomedicine·Elaheh Entezar-AlmahdiFatemeh Farjadian
Mar 28, 2019·Combinatorial Chemistry & High Throughput Screening·Jane Ru ChoiAlistair C Cowie
May 22, 2019·Macromolecular Rapid Communications·Nan ZhangXiaoling Hu
Jan 29, 2021·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Lang WuWenhua Geng
Jun 23, 2020·Current Topics in Medicinal Chemistry·Renuka SuravajhalaBabita Malik
Apr 21, 2021·Macromolecular Bioscience·Peihong LiChunling Zhang
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rui Liu, Alessandro Poma

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