Temperature and photoperiod affect the endocrine disruption effects of ethinylestradiol, nonylphenol and their binary mixture in zebrafish (Danio rerio)

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Yuanxiang JinZhengwei Fu

Abstract

We found that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, vitellogenin1 (Vtg1), vitellogenin2 (Vtg2), estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta), after a 21-day exposure to environmentally relevant concentrations of 17 alpha-ethynylestradiol (EE2), nonylphenol (NP) and EE2 plus NP (EE2+NP). In general, gene transcription levels were higher as temperature and photoperiod length increased. The mRNA levels of Vtg1 in EE2 (10 ng/L) and EE2+NP (10 ng/L and 25 microg/L, respectively) groups were induced more than 10(4) times both in 21 degrees C-12L and 30 degrees C-14L groups, but only 369+/-23 and 178+/-59-fold induced in 12 degrees C-10L group compared to the control, respectively. Specifically, when exposed to a high concentration of NP (25 microg/L) for 21 days, the levels of all mRNAs examined were significantly increased (p<0.05) in the 21 degrees C-12L and the 30 degrees C-14L groups compared to the controls. However, no obvious induction in transcription was observed in the 12 degrees C-10L group. The results obtained in the present study clearly elucidate that temperature and photoperiod greatly influence the effect of EDCs, and thus su...Continue Reading

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Citations

Aug 12, 2014·Ecotoxicology and Environmental Safety·Sangwoo LeeKyungho Choi
Apr 22, 2014·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Nasim Reyhanian CaspilloInger Porsch-Hällström
Jan 23, 2017·Bulletin of Environmental Contamination and Toxicology·Ernestina Perez-GonzalezMarcos Bucio-Pacheco
Oct 19, 2010·The Journal of Experimental Biology·Catriona H CondonRobbie S Wilson
Aug 22, 2021·Ecotoxicology and Environmental Safety·Yves Moreira RibeiroElizete Rizzo
Nov 3, 2021·Journal of Applied Toxicology : JAT·Yukio KawashimaTaisen Iguchi

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