Temperature-controlled chalcogenation and chalcogenocyanation of imidazopyridines in water under transition-metal-free conditions

The Journal of Organic Chemistry
Yu-Shen ZhuMao-Ping Song

Abstract

A sustainable and transition-metal-free approach for C3 chalcogenation and chalcogenocyanation of imidazopyridines with KXCN (X = S or Se) has been developed under mild conditions. Importantly, this reaction was performed in the presence of catalytic iodine in aqueous medium, which afforded either chalcogenated or chalcogenocyanated imid-azopyridines under temperature control. The current protocol featured broad substrate scope, transition-metal- and or-ganic solvent-free, operational convenience, and gram-scale production.

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Mar 14, 2018·The Journal of Organic Chemistry·Xiao-Niu CaoMao-Ping Song
Oct 24, 2018·The Journal of Organic Chemistry·Shuai LuMao-Ping Song
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Mar 21, 2019·The Journal of Organic Chemistry·Lu-Lu TianMao-Ping Song
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Dec 14, 2019·The Journal of Organic Chemistry·Changlei ZhiMao-Ping Song

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Citations

Nov 5, 2020·Organic & Biomolecular Chemistry·Zhen YangYu Wei
Aug 14, 2021·The Journal of Organic Chemistry·Yinrong WuXiaodong Tang
Nov 4, 2020·The Journal of Organic Chemistry·Shuang LiuMao-Ping Song

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