PMID: 3765705Jan 1, 1986Paper

Temperature dependence of bronchial and tracheal reactivity of isolated respiratory tract preparations of the guinea pig

Zeitschrift für Erkrankungen der Atmungsorgane
B MeyerC Gross

Abstract

The intrapulmonary loss of heat due to hyperventilation may be considered as essential pathogenetic factor in producing exercise induced asthmatic response. The temperature dependence of smooth muscle contraction was investigated using isolated trachea and isolated lung strips of guinea pigs. The measurements of the contraction responses to cumulative dose administrations of acetylcholine (10(-9) to 10(-3) M) were made in thermostated organ baths (isotonic contraction, modified Krebs-Henseleit solution, pH 7.4, air gassing). The standardized measurement data were adjusted to a non-linear function with the aid of a computer. The reactivity of the isolated trachea remained unchanged with a change of the bath temperature (from 37 degrees C to 30 degrees C), whereas a markedly increased contraction response to acetylcholine was observed in the lung strips. The results indicate that the contraction induced by the drop in temperature is localized in the small airways. The stabilization of reactive oxygen metabolites as an asthma-inducing mechanism is discussed as a possible explanation of the temperature-dependent effects.

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
J MokryG Nosálová
Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
M ChłopeckaM Wiechetek
© 2021 Meta ULC. All rights reserved