PMID: 6536291Jul 1, 1984Paper

Temperature dependence of ethanol depression in C57BL/6 and BALB/c mice

Alcohol
J R Wenger, R L Alkana

Abstract

The relationship between environmental temperature, body temperature and brain sensitivity to ethanol was investigated in male C57BL/6S and BALB/cS mice. Age-matched, drug-naive mice of both strains were injected with 3.6 g/kg ethanol (20% w/v) and placed into a chamber kept at one of eight designated temperatures from 12 to 36 degrees C. Chamber temperature significantly affected wake-up rectal temperatures, sleep-times and wake-up brain ethanol concentrations in the intoxicated mice. Wake-up rectal temperatures were significantly, positively correlated with sleep-times and significantly, negatively correlated with wake-up brain ethanol concentrations in both strains. Linear regression analyses indicated that up to 47% of the variability in ethanol sensitivity of C57 mice and up to 31% of the variability in sensitivity of BALB mice could be accounted for by their wake-up rectal temperatures suggesting that the effects of ambient temperature on ethanol sensitivity were mediated, in part, by the resultant body temperatures. These results replicate and extend previous findings and demonstrate that temperature dependence of ethanol depression is not strain specific. The correlational and regression analyses provide additional evid...Continue Reading

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Citations

Jan 1, 1987·Psychopharmacology·M BejanianR L Alkana
Jan 1, 1987·Physiology & Behavior·C L Cunningham, L L Bischof
Aug 1, 1985·Pharmacology, Biochemistry, and Behavior·R L AlkanaD A Finn
Oct 1, 1989·Pharmacology, Biochemistry, and Behavior·D A FinnR L Alkana
Jun 1, 1991·Pharmacology, Biochemistry, and Behavior·M BejanianR L Alkana
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·C S O'ConnorJ C Crabbe
May 1, 1987·Alcohol·E Romm, A C Collins
Jul 1, 2000·Addiction Biology·S BellentaniC Tiribelli
Aug 1, 1991·Alcoholism, Clinical and Experimental Research·D A FinnR L Alkana
Oct 1, 1991·Alcoholism, Clinical and Experimental Research·A C MezzichD H Van Thiel
Apr 1, 1994·Alcoholism, Clinical and Experimental Research·D A FinnR L Alkana
Dec 1, 1996·Alcoholism, Clinical and Experimental Research·G L Schafer, J C Crabbe
Oct 2, 1998·Alcoholism, Clinical and Experimental Research·M E MattsonA Zweben

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