Temperature-induced interconversion of alpha-and beta-adrenoceptors in the frog heart

The Journal of Physiology
G Kunos, M Nickerson

Abstract

1. The effect of ambient temperature on the properties of adrenoceptors mediating inotropic responses was assessed in isolated frog hearts on the basis of the effects and tissue uptake of alpha- and beta-adrenoceptor antagonists. 2. At temperatures of 23degree C and above inotropic responses to adrenaline were antagonized by propranolol (0-4-4-0muM), but were unaffected by phentolamine (26-5muM) and were potentiated by phenoxybenzamine (POB) (0-7-29-5muM). Below 17degree C the activity of propranolol was reduced at least tenfold, and the alpha-adrenoceptor antagonists inhibited responses to both adrenaline and isoprenaline, but not those to CaCL2. 3. The responses of hearts exposed to POB at 14degree C and then tested, after thorough washing, at both 14 and 24degree C were similarly inhibited at both temperatures, i.e. the usual beta-adrenoceptor response did not appear at the higher temperature. Conversely, exposure to POB at 24degree C produced only potentiation at both test temperatures. 4. Parallel to the reciprocal changes in their blocking actions, significantly more (14C)propranolol was retained by hearts exposed at high temperatures and significantly more (3H)POB was bound to the myocardium at low temperatures. Changes ...Continue Reading

Citations

Jul 1, 1977·Acta Pharmacologica Et Toxicologica·A Carlsten, O Poupa
Apr 1, 1977·British Journal of Pharmacology·G Kunos, M Nickerson
Feb 1, 1990·Journal of the Royal Society of Medicine·E D Cooke, C Ward
Jun 1, 1983·Journal of Clinical and Hospital Pharmacy·R Vogel
Jul 13, 2002·The Journal of Experimental Zoology·Antigone LazouAnastasia Pehtelidou
Feb 1, 1979·Circulation Research·G I Drummond, D L Severson
Oct 1, 1986·The Journal of Experimental Zoology·C A HermanR S Heller
May 5, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·J Wagner, O E Brodde
Nov 1, 1992·Anaesthesia and Intensive Care·A S McLean
Mar 1, 1991·Fish Physiology and Biochemistry·T P JohnsonI A Johnston
Sep 1, 1986·Cellular and Molecular Neurobiology·A HirataN Akaike
May 1, 1984·Circulation Research·J P CookeP M Vanhoutte
Jan 1, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·T Bennett, P A Kemp
Jan 1, 1981·CRC Critical Reviews in Biochemistry·A Levitzki
Dec 21, 1994·Molecular and Cellular Biochemistry·M V PetroffA Mattiazzi
Sep 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·J L Morris
Jan 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·J L MorrisJ Clevers
Nov 1, 1980·Acta Pharmacologica Et Toxicologica·A CarlstenS Winell
Jan 1, 1981·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·G Stene-Larsen
Jan 1, 1982·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·S Holmgren, S Nilsson
Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A Pinto, D Piomelli
Apr 15, 1984·Biochemical Pharmacology·J S FedanJ P O'Donnell
Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·K W Chiu, J Y Chu
Jan 1, 1983·Comparative Biochemistry and Physiology. A, Comparative Physiology·J A Ask
Feb 7, 1977·Biochemical and Biophysical Research Communications·T Ciaraldi, G V Marinetti
May 8, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Cristian SevcencuCorneliu Tarba

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.