Temperature-Induced Surface Effects on Drug Nanosuspensions

Pharmaceutical Research
Simone AleandriMartin Kuentz

Abstract

The trial-and-error approach is still predominantly used in pharmaceutical development of nanosuspensions. Physicochemical dispersion stability is a primary focus and therefore, various analytical bulk methods are commonly employed. Clearly less attention is directed to surface changes of nanoparticles even though such interface effects can be of pharmaceutical relevance. Such potential effects in drug nanosuspensions were to be studied for temperatures of 25 and 37°C by using complementary surface analytical methods. Atomic force microscopy, inverse gas chromatography and UV surface dissolution imaging were used together for the first time to assess pharmaceutical nanosuspensions that were obtained by wet milling. Fenofibrate and bezafibrate were selected as model drugs in presence of sodium dodecyl sulfate and hydroxypropyl cellulose as anionic and steric stabilizer, respectively. It was demonstrated that in case of bezafibrate nanosuspension, a surface modification occurred at 37°C compared to 25°C, which notably affected dissolution rate. By contrast, no similar effect was observed in case of fenofibrate nanoparticles. The combined usage of analytical surface methods provides the basis for a better understanding of phenomen...Continue Reading

References

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Citations

May 11, 2020·Mini Reviews in Medicinal Chemistry·Yue XingZhidong Liu
Aug 31, 2021·Advanced Drug Delivery Reviews·Benedict BrownKofi Asare-Addo

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Methods Mentioned

BETA
atomic force microscopy
AFM
X-Ray
dynamic light scattering

Software Mentioned

iGC
EVA Application
Actipix®SDI300
DSC

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