Temperature mapping of laser-induced hyperthermia in an ocular phantom using magnetic resonance thermography

Journal of Biomedical Optics
Saher M MaswadiRandolph D Glickman

Abstract

Laser-induced heating in an ocular phantom is measured with magnetic resonance thermography (MRT) using temperature-dependent phase changes in proton resonance frequency. The ocular phantom contains a layer of melanosomes isolated from bovine retinal pigment epithelium. The phantom is heated by the 806-nm output of a continuous wave diode laser with an irradiance of 2.4 to 21.6 W/cm2 in a beam radius of 0.8 or 2.4 mm, depending on the experiment. MRT is performed with a 2 T magnet, and a two-turn, 6-cm-diam, circular radio frequency coil. Two-dimensional temperature gradients are measured within the plane of the melanin layer, as well as normal to it, with a temperature resolution of 1 degrees C or better. The temperature gradients extending within the melanin layer are broader than those orthogonal to the layer, consistent with the higher optical absorption and consequent heating in the melanin. The temperature gradients in the phantom measured by MRT closely approximate the predictions of a classical heat diffusion model. Three-dimensional temperature maps with a spatial resolution of 0.25 mm in all directions are also made. Although the temporal resolution is limited in the prototype system (22.9 s for a single image "slice"...Continue Reading

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Citations

Jun 28, 2012·Journal of Biomedical Optics·Kerstin SchlottRalf Brinkmann
Jan 2, 2010·Biomedical Engineering Online·Ward SmallDuncan J Maitland
May 24, 2011·Advances in Colloid and Interface Science·Sophie LaurentMorteza Mahmoudi

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