Temperature regulation in depression: functional 5HT1A receptor adaptation differentiates antidepressant response

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
J L RauschS M Stahl

Abstract

Observations in humans and animals have indicated that chronic, but not acute, antidepressant treatment (ADT) can desensitize 5-HT1A receptor-mediated responses, such as hypothermia. We hypothesized that 5-HT1A desensitization would be necessary for an antidepressant response (ADR) to occur. To test this hypothesis, we examined 5HT1A-agonist ipsapirone (IPS)-induced hypothermia in 28 depressed patients being treated with fixed doses of nortriptyline (75 mg) at 3-day and 3-week treatment points. Decreases in 24-item Hamilton scores (>12) were used to dichotomize the response data into ADR groups of 13 responders (ADR+) and 15 nonresponders (ADR-). A two-way repeated measures analysis of variance indicated significant temperature differences in the area under the curve between response groups across time from 3-day to 3-week intervals (df=1, 26, F=6.6, p<0.02). In comparison to 3 days treatment, at 3 weeks, the ADR+ patients showed blunted hypothermic responses to IPS. ADR- did not show this effect, implicating ADR+ patients to be less responsive to 5HT1A-receptor stimulation after 3 weeks treatment. Similar effects were not found for 5HT1A postsynaptically mediated ACTH and cortisol responses. These results indicate that to achi...Continue Reading

References

Jul 1, 1976·Archives of General Psychiatry·B ShopsinS Gershon
Jul 1, 1992·British Journal of Pharmacology·M T O'ConnellG Curzon
Feb 18, 1992·European Journal of Pharmacology·P Blier, C Bouchard
Jan 1, 1990·Journal of Neural Transmission. General Section·K P LeschA Schmidtke
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·G M Goodwin
Jun 1, 1988·Pharmacology, Biochemistry, and Behavior·K M WozniakD L Murphy
Sep 1, 1988·Acta Psychiatrica Scandinavica·M MuijenM Christie
Jan 1, 1985·Journal of Neural Transmission·S Hjorth
Jan 1, 1981·Acta Psychiatrica Scandinavica. Supplementum·S A MontgomeryD B Montgomery
Aug 1, 1997·Psychopharmacology·P SargentP J Cowen
May 18, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B LererM E Newman
Feb 23, 2000·Neuroreport·D K KimB J Carroll
Oct 12, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B G PollockD J Kupfer
Apr 6, 2001·Neurochemistry International·B N SrinivasK Y Vinod
Jul 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pierre BlierChawki Benkelfat
Oct 24, 2002·Journal of Psychiatric Research·Jakob M KochJosef B Aldenhoff
Mar 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A Bortolozzi, F Artigas
Mar 18, 2003·Journal of Clinical Psychopharmacology·Jeffrey L RauschMaria E Johnson
Jun 27, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hans Liljenström
May 6, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nasser HaddjeriPierre Blier
May 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ettore TiraboschiMaurizio Popoli

❮ Previous
Next ❯

Citations

Jun 1, 2012·International Journal of Peptides·Brian HallKeith K Parker
Dec 12, 2012·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·David R P Guay
Sep 23, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sakina J Rizvi, Sidney H Kennedy
May 12, 2009·Progress in Neurobiology·Jonathan SavitzWayne C Drevets
Mar 6, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·N R MirzaK B Troelsen
Apr 29, 2014·Journal of Affective Disorders·Suhayl NasrJohn Crayton
Nov 5, 2010·International Review of Psychiatry·Robert Keers, Katherine J Aitchison
May 12, 2011·The International Journal of Neuropsychopharmacology·Malika El YacoubiJean-Marie Vaugeois
May 23, 2013·Molecular BioSystems·Shiro YanoHajime Asama
Oct 26, 2013·Chronobiology International·Jelena MrdaljJanne Grønli
Sep 22, 2009·Expert Opinion on Investigational Drugs·Arif Khan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.