Temperature regulation of the streptococcal pyrogenic exotoxin A-encoding gene (speA).

Infection and Immunity
S Xu, C M Collins

Abstract

The gene encoding the bacterial superantigen streptococcal pyrogenic exotoxin A is often found in streptococcal strains associated with the recently described streptococcal toxic shock syndrome. Here we demonstrate that this gene is expressed at approximate fourfold higher levels in cells grown at 37 degrees C when compared to cells grown at 26 degrees C. This suggests there is increased production of this toxin when Streptococcus pyogenes is found in infections of the soft tissues and bloodstream, as opposed to S. pyogenes that have not breached the epithelial layers and are living on the surface of the skin.

References

Jan 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D L Stevens
Jan 1, 1991·Methods in Enzymology·M G Caparon, J R Scott
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J M MusserR K Selander
May 1, 1993·The Journal of Infectious Diseases·P M Schlievert
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Citations

Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·L M SmootJ M Musser
Dec 7, 2006·Scandinavian Journal of Infectious Diseases·Gunilla GoscinskiJan Sjölin
Mar 30, 1999·Molecular Microbiology·A PodbielskiK H Schmidt
Jul 25, 2000·Clinical Microbiology Reviews·M W Cunningham

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