Temperature responses of mutation rate and mutational spectrum in an Escherichia coli strain and the correlation with metabolic rate

BMC Evolutionary Biology
Xiao-Lin ChuDa-Yong Zhang

Abstract

Temperature is a major determinant of spontaneous mutation, but the precise mode, and the underlying mechanisms, of the temperature influences remain less clear. Here we used a mutation accumulation approach combined with whole-genome sequencing to investigate the temperature dependence of spontaneous mutation in an Escherichia coli strain. Experiments were performed under aerobic conditions at 25, 28 and 37 °C, three temperatures that were non-stressful for the bacterium but caused significantly different bacterial growth rates. Mutation rate did not differ between 25 and 28 °C, but was higher at 37 °C. Detailed analyses of the molecular spectrum of mutations were performed; and a particularly interesting finding is that higher temperature led to a bias of mutation to coding, relative to noncoding, DNA. Furthermore, the temperature response of mutation rate was extremely similar to that of metabolic rate, consistent with an idea that metabolic rate predicts mutation rate. Temperature affects mutation rate and the types of mutation supply, both being crucial for the opportunity of natural selection. Our results help understand how temperature drives evolutionary speed of organisms and thus the global patterns of biodiversity. T...Continue Reading

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Oct 11, 2019·Environmental Microbiology·Thomas Ferenci
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Jul 25, 2021·Genome Research·Ann-Marie Waldvogel, Markus Pfenninger
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Datasets Mentioned

BETA
PRJNA383601

Software Mentioned

SAMTOOLS
SMRT portal
BLAST
GeneMarkS

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