Temperature-Responsive Poly(N -Isopropylacrylamide) Nanogels: The Role of Hollow Cavities and Different Shell Cross-Linking Densities on Doxorubicin Loading and Release

Langmuir : the ACS Journal of Surfaces and Colloids
Sakineh HajebiMehdi Salami-Kalajahi

Abstract

Smart polymers with extraordinary characteristics are studied in drug-delivery applications. In the current study, temperature-responsive hybrid core-shell nanoparticles were synthesized by precipitation polymerization of N-isopropylacrylamide and vinyl-modified silica nanoparticles. These temperature-responsive hybrid core-shells were prepared with different cross-linking densities by using 2, 4, and 8 mol % of N,N-methylene bisacrylamide (MBA). Hydrolysis of the silica cores of the hybrid core-shells resulted in hollow poly(N-isopropylacrylamide) (PNIPAM) nanogels. Functionalization of silica nanoparticles with vinyl-containing silane modifier of 3-(trimethoxysilyl) propyl methacrylate (MPS) in two different contents was proven by Fourier transform infrared spectroscopy. Preparation of the hybrid PNIPAM nanogels and etching of the silica cores were studied using thermogravimetric analysis and also electron microscopy imaging. Sensitivity of the PNIPAM nanogel samples to temperature was studied using ultraviolet-visible (UV-vis) spectroscopy. In addition, dynamic light scattering was used for investigation of the squeezing and expansion of the hybrid and hollow samples against variation of temperature. The UV-vis spectroscopy ...Continue Reading

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Citations

Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maxim DirksenThomas Hellweg
Sep 15, 2021·ACS Applied Materials & Interfaces·Weinan ChenHui Xie
Nov 4, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Nobuyuki MorimotoFrançoise M Winnik

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