Temperature sensitive dopamine-imprinted (N,N-methylene-bis-acrylamide cross-linked) polymer and its potential application to the selective extraction of adrenergic drugs from urine

Journal of Chromatography. a
R SuedeeG P Martin

Abstract

A temperature sensitive dopamine-imprinted polymer was prepared in 80% aqueous methanol solution by free-radical cross-linking co-polymerisation of methacrylic acid and acrylamide at 60 degrees C in the presence of N,N-methylene-bis-acrylamide as the cross-linker and dopamine hydrochloride as template molecule. The resulting molecularly imprinted polymer (MIP) formed temperature responsive materials, which could be used for the selective separation of appropriate dopamine and adrenergic compounds from a liquid matrix at ambient temperatures. The thermoresponsive MIP exhibited a swelling-deswelling transition in 80% aqueous methanol solution at about 35 degrees C. The capacity of the thermoresponsive MIP to recognise the template molecule when present in aqueous methanol solution changed with temperature, with the highest selectivity found at 35 degrees C. Additionally, binding parameters obtained from Scatchard analyses indicate that increasing temperature resulted in an increased affinity and binding capacity of specific binding sites, but had less effect on non-selective binding sites. Subsequently, the thermoresponsive MIP was tested for its application as a sorbent material, utilisable in the selective solid-phase extractio...Continue Reading

References

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Citations

May 1, 2007·Analytical and Bioanalytical Chemistry·Sarah M R Wille, Willy E E Lambert
Jun 5, 2007·Analytical and Bioanalytical Chemistry·Xiaoman JiangMancang Liu
Oct 22, 2011·International Journal of Molecular Sciences·Giuseppe VasapolloGiuseppe Mele
Mar 31, 2009·International Journal of Molecular Sciences·Roongnapa SuedeeBhutorn Canyuk
Jun 12, 2014·Analytical and Bioanalytical Chemistry·Xuan SunZhao-Sheng Liu
Sep 22, 2011·Expert Opinion on Drug Delivery·Francesco PuociNevio Picci
Mar 23, 2011·Biosensors & Bioelectronics·Tatsuro Goda, Yuji Miyahara
Mar 5, 2016·Chemical Society Reviews·Lingxin ChenJinhua Li
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Feb 17, 2009·Journal of Separation Science·Martina Lasáková, Pavel Jandera
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Nov 17, 2006·Journal of Biochemical and Biophysical Methods·Chiyang HeFeng Liu
Apr 26, 2015·Analytical and Bioanalytical Chemistry·Rosa A LorenzoCarmen Alvarez-Lorenzo
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Dec 15, 2020·Journal of Chromatography. a·Javier González-SálamoJavier Hernández-Borges

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