Temperature-sensitive liposomes for co-delivery of tamoxifen and imatinib for synergistic breast cancer treatment

Journal of Liposome Research
Anup JoseVenkata Vamsi Krishna Venuganti

Abstract

Co-delivery of chemotherapeutic agents using nanocarriers is a promising strategy for enhancing therapeutic efficacy of anticancer agents. The aim of this work was to develop tamoxifen and imatinib dual drug loaded temperature-sensitive liposomes to treat breast cancer. Liposomes were prepared using 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), monopalmitoyl-2-hydroxy-sn-glycero-3-phosphocholine (MPPC), and different surface active agents. The liposomes were characterized for the average particle size, zeta potential, transition temperature, and drug release below and above liposomal transition temperature. The temperature-sensitive liposomes co-encapsulated with tamoxifen and imatinib were investigated for their synergistic activity against MCF-7 and MDA-MB-231 breast cancer cells. The liposomal nanoparticles showed a transition temperature of 39.4 °C and >70% encapsulation efficiency for tamoxifen and imatinib. The temperature-responsive liposomes showed more than 80% drug released within 30 min above transition temperature. Dual drug loaded liposomes showed synergistic growth inhibition against MCF-7 and MDA-MB-231 breast cancer cells. Co-delivery of tamoxifen and imatinib using temperature-sensitive liposomes can be ...Continue Reading

References

Jan 1, 1988·Urological Research·S SzmigielskiG Pulverer
Jan 1, 1984·Journal of Steroid Biochemistry·G L GreeneE V Jensen
May 1, 1995·Journal of Microencapsulation·S B KulkarniM Singh
Apr 21, 1993·Journal of the National Cancer Institute·P M Chaudhary, I B Roninson
Sep 8, 2000·BMJ : British Medical Journal·K McPhersonJ M Dixon
Aug 16, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J van der Zee
Aug 16, 2002·The New England Journal of Medicine·George D DemetriHeikki Joensuu
Mar 15, 2003·JAMA : the Journal of the American Medical Association·Christopher I LiRoger E Moe
Jan 5, 2007·Journal of the National Cancer Institute·Ana M PonceMark W Dewhirst
Mar 3, 2007·The Lancet Oncology·Susan CleatorR Charles Coombes
Jun 3, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M CristofanilliG N Hortobagyi
Aug 28, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fabienne DanhierVéronique Préat
Jun 22, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jun GuoShukui Qin
Aug 25, 2011·Nature Reviews. Clinical Oncology·Nicholas B La Thangue, David J Kerr
Jan 25, 2012·Journal of Drug Delivery·E MonteagudoA M Carlucci
Nov 8, 2012·The Journal of Physical Chemistry. B·Sureshbabu NagarajanR Brian Dyer
Jul 6, 2014·The Lancet Oncology·Roelof W F van LeeuwenFrank G A Jansman
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Sandeep Kalepu, Vijaykumar Nekkanti
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 20, 2016·Journal of Nanobiotechnology·Yu-Ling LinKuang-Wen Liao
Mar 19, 2016·Signal Transduction Insights·Subrata Manna, Marina K Holz

❮ Previous
Next ❯

Citations

Mar 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Candace M DaySanjay Garg
Jul 3, 2020·Chemical & Pharmaceutical Bulletin·Shintaro Fumoto, Koyo Nishida
Mar 7, 2020·International Journal of Pharmaceutics·Francesca RolleSilvia Arpicco
May 1, 2021·International Journal of Molecular Sciences·Vrinda GoteDhananjay Pal
May 12, 2021·Cellular and Molecular Life Sciences : CMLS·Biyao YangWei Deng
May 26, 2021·Life Sciences·Behrouz Foroughi-NiaSoudabeh Davaran
Jul 17, 2021·Global Challenges·Pantelitsa DimitriouDavid Barrow
Jul 6, 2020·Drug Discovery Today·Mahdi ZeinaliMichael R Hamblin
Jul 21, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ahmed RefaatKarlheinz Peter
Jan 16, 2021·ACS Applied Materials & Interfaces·Lin LiHaitao Ran
Nov 3, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Wakana SatoKatarzyna P Adamala

❮ Previous
Next ❯