PMID: 4890619Apr 1, 1969Paper

Temperature-sensitive mutants of respiratory syncytial virus

Journal of Virology
M A GharpureR M Chanock

Abstract

Four conditional-lethal temperature-sensitive mutants of RS virus were detected among the progeny of 454 plaques derived from virus grown in the presence of 10(-4)m 5-fluorouridine. These mutants were stable (reversion frequency, 10(-5.0) or less and failed to produce plaques at 38 or 39 C. Plaquing efficiency was depressed 100-fold or more at 37 C. Variable suppression of growth at the restrictive temperature of 39 C was observed, ranging from 16-fold to complete suppression. The temperature-sensitive defect of three of the mutants appeared to affect functions which were expressed late in the replicative cycle. One of the mutants produced atypical nonsyncytial plaques.

References

Nov 24, 1966·The New England Journal of Medicine·C B SmithR M Chanock
Jan 1, 1967·Archiv für die gesamte Virusforschung·B Bloth, E Norrby
Dec 1, 1960·Biochemical and Biophysical Research Communications·J D MANDELL, J GREENBERG
Nov 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·J W MOSLEY, J F ENDERS

❮ Previous
Next ❯

Citations

Jan 1, 1978·Journal of Medical Virology·L S RichardsonR M Chanock
Jan 1, 1985·Archives of Virology·E J Stott, G Taylor
Jan 1, 1972·Archiv für die gesamte Virusforschung·B Simizu, N Takayama
Jan 1, 1973·Archiv für die gesamte Virusforschung·A R KalicaR M Chanock
Jan 1, 1970·Archiv für die gesamte Virusforschung·M F Paccaud, C Jacquier
Oct 1, 1984·The Journal of Hygiene·E J StottS Crouch
Jan 1, 1973·Archiv für die gesamte Virusforschung·P F WrightR M Chanock
Oct 8, 2019·Expert Review of Vaccines·Iebe Rossey, Xavier Saelens
Jan 25, 2006·The Journal of General Virology·Patrick J BraniganAlfred M Del Vecchio
Mar 7, 2018·The Journal of Infectious Diseases·Fernando P Polack
Mar 26, 2021·Influenza and Other Respiratory Viruses·Jing ShanRobert Booy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.