PMID: 2882934Jan 1, 1987Paper

Temperature sensitivity of cardiac muscarinic receptors in bat atria and ventricle

Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
J E O'Shea

Abstract

In contrast to other mammals, muscarinic receptors in the bat ventricle can mediate significant decrease in basal contractile force (greater than 50%), not only at 37 degrees C but also at hibernation temperature (12 degrees C). At frequencies of contraction that approximate in vivo values for 37-12 degrees C, no significant shift in receptor affinity or maximum response to applied acetylcholine was found for either ventricular or atrial muscle. Low temperature does not appear to compromise receptor function in hibernators. The atypical cholinergic innervation of the ventricle may maintain a regulative role during hibernation.

References

Feb 24, 1976·Pflügers Archiv : European journal of physiology·R Ten EickW Trautwein
Nov 1, 1975·Clinical and Experimental Pharmacology & Physiology·D R RichmondL B Cobbin
Jan 1, 1976·The Journal of Physiology·K A Edman, M Jóhannsson
Feb 1, 1970·Canadian Journal of Physiology and Pharmacology·J Mejsnar, L Janský
Oct 31, 1980·European Journal of Pharmacology·N T PhanP V Sulakhe
Jan 1, 1962·The Journal of General Physiology·S WINEGRAD, A M SHANES
Oct 1, 1963·The Journal of Physiology·C P LYMAN, R C O'BRIEN

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Citations

Feb 22, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·W K MilsomM B Harris

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