Temperature sensitivity of DNA synthesis in mouse testicular germ cells in vitro

Experimental Cell Research
Y Nishimune, S Aizawa


The effect of temperature on testicular DNA synthesis in mice was studied in vitro. By using cultures of cryptorchid testis, DNA synthesis of differentiated germ cells, such as intermediate and type B spermatogonia and resting primary spermatocytes, was shown to be temperature-sensitive, while that of undifferentiated type A spermatogonia was not. DNA synthesis of non-germ cells was not temperature-sensitive. This temperature sensitivity of germ cells in DNA synthesis may be one cause of the thermal inhibition of germ cell differentiation.


Feb 28, 2003·Biology of Reproduction·Makoto NaganoRalph L Brinster
Oct 20, 2005·Journal of Bioscience and Bioengineering·S RyokiT Muramatsu
Oct 15, 1982·Biochemical and Biophysical Research Communications·T HanejiY Nishimune
Jan 1, 1987·Archives of Andrology·M NakamuraT Sonoda
Jan 1, 1989·Archives of Andrology·M FujisawaS Kamidono
Oct 1, 1980·Journal of Cellular Physiology·Y NishimuneY Kitamura
Mar 1, 1995·Andrologia·S C RubensteinA Morgentaler


Dec 1, 1972·Experimental Cell Research·Y Nishimune, T Komatsu
Feb 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·R G HAM

Related Concepts

Cockayne Syndrome
Culture Techniques
Cell Differentiation Process
Seminiferous Tubule Structure
DNA Replication
Unilateral Cryptorchidism
Mice, Inbred C57BL

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