PMID: 4909468Apr 1, 1970Paper

Template activity of liver chromatin increased by in vivo administration of insulin

Proceedings of the National Academy of Sciences of the United States of America
C R Morgan, J Bonner

Abstract

The hypothesis that insulin may serve as a derepressor of genetic information in the liver of diabetic rats has been tested by comparing the template activity for RNA synthesis of chromatin from liver of insulin-treated diabetic rats to that of chromatin from liver of insulin-deficient diabetic rats. The template activity of the chromatins of insulin-treated diabetic rats is found to be 28 per cent greater than that of chromatin from liver of diabetic rats not treated with insulin. Time course studies show that the template activity of liver chromatin of rats injected with a single dose of insulin reaches a peak at two hours, which is some hours before the appearance of a typical insulin-induced liver enzyme, glucokinase. We conclude that insulin derepresses genetic material of the diabetic liver genome that is repressed in the absence of insulin.

References

Nov 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·M E Dahmus, J Bonner
Jul 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·A G Matthysse, C Phillips
Jan 1, 1966·Journal of Molecular Biology·K Marushige, J Bonner
Aug 14, 1967·Journal of Molecular Biology·H R Maurer, G R Chalkley

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Citations

Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·E KöhlerF Wojnorowicz
May 1, 1974·Acta diabetologica latina·E PimentelF González-Mujica
Aug 16, 1973·Life Sciences·S H QuarfordtH Hilderman
Jan 1, 1972·Advances in Enzyme Regulation·D M GibsonY Muto
May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·I D Goldfine, G J Smith
Jun 9, 1972·European Journal of Biochemistry·M Oravec, A Korner
Nov 16, 1972·Biochimica Et Biophysica Acta·T V Gopalakrishnan, A Sadgopal
Sep 24, 1971·Biochimica Et Biophysica Acta·F A Dati, H R Maurer
Aug 1, 1973·Experimental Cell Research·B I Srivastava
Jun 21, 1982·Journal of Theoretical Biology·J Schole
Sep 1, 1977·Archives of Biochemistry and Biophysics·I T Mak, W W Wells
Jun 1, 1984·Medical Hypotheses·B Younkin, B Gudzinowicz
Oct 21, 1978·Journal of Theoretical Biology·B Younkin, H Martin
Jan 20, 1975·Biochemical and Biophysical Research Communications·R L Drake, C R Morgan
Oct 1, 1982·Molecular and Cellular Biochemistry·I D Goldfine Vigneri
Jan 1, 1982·Journal of Cellular Biochemistry·I D GoldfineR Vigneri

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