Template directed replication supports the maintenance of the metabolically coupled replicator system

Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life
Balázs Könnyű, Tamás Czárán

Abstract

The RNA World scenario of prebiotic chemical evolution is among the most plausible conceptual framework available today for modelling the origin of life. RNA offers genetic and catalytic (metabolic) functionality embodied in a single chemical entity, and a metabolically cooperating community of RNA molecules would constitute a viable infrabiological subsystem with a potential to evolve into proto-cellular life. Our Metabolically Coupled Replicator System (MCRS) model is a spatially explicit computer simulation implementation of the RNA-World scenario, in which replicable ribozymes cooperate in supplying each other with monomers for their own replication. MCRS has been repeatedly demonstrated to be viable and evolvable, with different versions of the model improved in depth (chemical detail of metabolism) or in extension (additional functions of RNA molecules). One of the dynamically relevant extensions of the MCRS approach to prebiotic RNA evolution is the explicit inclusion of template replication into its assumptions, which we have studied in the present version. We found that this modification has not changed the behaviour of the system in the qualitative sense, just the range of the parameter space which is optimal for the ...Continue Reading

References

Aug 9, 1979·Nature·J M Smith
Oct 21, 1987·Journal of Theoretical Biology·E Szathmáry, L Demeter
May 9, 1989·Journal of Theoretical Biology·E Szathmáry, I Gladkih
Jun 5, 2003·Chaos·Gyorgy KarolyiTamas Czaran
Sep 30, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Eörs Szathmáry
Sep 30, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·James P Ferris
Sep 28, 2007·Bioorganic Chemistry·Shelley D CopleyHarold J Morowitz

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Citations

Nov 20, 2016·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·David A Baum, Kalin Vetsigian

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