Template-directed supramolecular assembly of a new type of nanoporous peptide-based material

Journal of Peptide Science : an Official Publication of the European Peptide Society
C H Görbitz, Frode Rise

Abstract

Dipeptides with two hydrophobic residues are known to often form crystals with hydrophobic or hydrophilic channels. One of the exceptions is Leu-Ile, which has been previously shown to crystallize as a nonporous 0.75 hydrate in the hexagonal space group P6(1) with Z' = 4. We have now found that in the presence of D-Leu, a second pseudopolymorph of the dipeptide is formed. The crystal structure has hydrophilic, water-filled channels with an irregular cross section of approximately 5.5 x 3.5 A and constitutes the first example of a crystal packing arrangement where the direction of the channels is perpendicular to the direction of hydrophobic stacking of side chains rather than parallel as in all other porous peptide-based materials.

References

Aug 16, 2000·Acta Crystallographica. Section B, Structural Science·B Dalhus, C H Gorbitz
Jan 5, 2002·Chemistry : a European Journal·C H Görbitz
Sep 27, 2002·Acta Crystallographica. Section B, Structural Science·Carl Henrik Görbitz
Apr 26, 2003·Science·Meital Reches, Ehud Gazit
Apr 30, 2004·Chemical Communications : Chem Comm·Yujiang SongJohn A Shelnutt
Jan 4, 2007·Chemistry : a European Journal·Carl Henrik Görbitz

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Citations

Aug 28, 2010·Science·J RaboneM J Rosseinsky
Sep 4, 2009·Interdisciplinary Perspectives on Infectious Diseases·Edouard Vannier, Peter J Krause
Mar 6, 2012·Journal of Peptide Science : an Official Publication of the European Peptide Society·Marat A ZiganshinDmitry V Soldatov
Jun 22, 2018·Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials·Carl Henrik Görbitz
Jun 17, 2016·Acta Crystallographica. Section E, Crystallographic Communications·Carl Henrik Görbitz
Dec 7, 2010·Nanoscale·Karsten Brandt AndersenWinnie Edith Svendsen
Jan 2, 2010·Journal of the American Chemical Society·Upadhyayula S RaghavenderPadmanabhan Balaram
Jun 7, 2011·The Journal of Physical Chemistry. B·Upadhyayula Surya RaghavenderPadmanabhan Balaram

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