Template synthesis and physico-chemical characterization of 14-membered tetraimine macrocyclic complexes, [MLX(2)] [M=Co(II), Ni(II), Cu(II) and Zn(II)]. DNA binding study on [CoLCl(2)] complex

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Farha FirdausMohammad Shakir

Abstract

The template condensation reaction between glyoxal and 1,8-diaminonaphthalene resulted a few novel mononuclear 14-membered tetraimine macrocyclic complexes of the type, [MLX(2)] [M=Co(II), Ni(II), Cu(II) and Zn(II), for X=Cl or NO(3)]. The stoichiometry and the nature of the complexes have been deduced from the results of elemental analyses and conductance data. The formation of macrocyclic framework has been inferred from the appearance of imine upsilon(CN) and upsilon(MN) band in IR spectra and the resonance signals observed in (1)H and (13)C-NMR spectra. However, the overall geometry of the complexes has been assigned on the positions of bands in electronic spectra and magnetic moment data. The distortion in Cu(II) complexes has been deduced on EPR data. The thermal behavior of these complexes has been studied by TGA analysis. Absorption and circular dichroism studies on the complex proved a significant binding to calf thymus DNA.

References

Sep 8, 2004·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Sulekh Chandra, Lokesh Kumar Gupta
Jun 8, 2007·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·P Muralidhar ReddyVadde Ravinder

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Citations

Mar 27, 2013·Drug and Chemical Toxicology·Omar F KhabourFatima T Esmadi
May 12, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Lucia AndrezálováZdeňka Duračková
Jan 3, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·P Muralidhar ReddyV Ravinder
Mar 3, 2021·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ramaiah KonakanchiLaxma Reddy Kotha

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