Tempol, a Membrane-Permeable Radical Scavenger, Exhibits Anti-Inflammatory and Cardioprotective Effects in the Cerulein-Induced Pancreatitis Rat Model

Oxidative Medicine and Cellular Longevity
Andrzej MarciniakKatarzyna Lasiecka

Abstract

To date, it remains unclear whether mild form of acute pancreatitis (AP) may cause myocardial damage which may be asymptomatic for a long time. Pathogenesis of AP-related cardiac injury may be attributed in part to ROS/RNS overproduction. The aim of the present study was to evaluate the oxidative stress changes in both the pancreas and the heart and to estimate the protective effects of 1-oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine (tempol) at the early phase of AP. Cerulein-induced AP led to the development of acute edematous pancreatitis with a significant decrease in the level of sulfhydryl (-SH) groups (oxidation marker) both in heart and in pancreatic tissues as well as a substantial increase in plasma creatine kinase isoenzyme (CK-MB) activity (marker of the heart muscle lesion) which confirmed the role of oxidative stress in the pathogenesis of cardiac damage. The tempol treatment significantly reduced the intensity of inflammation and oxidative damage and decreased the morphological evidence of pancreas injury at early AP stages. Moreover, it markedly attenuated AP-induced cardiac damage revealed by normalization of the -SH group levels and CK-MB activity. On the basis of these studies, it is possible to conclude that ...Continue Reading

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Citations

Apr 22, 2017·Medical Science Monitor Basic Research·Linlin JingHuiping Ma
Jun 12, 2019·International Journal of Molecular Sciences·Pedro Silva-VazJosé Guilherme Tralhão
Sep 1, 2017·Scientific Reports·Vikas BhardwajAlexander I Zaika
Oct 8, 2020·Cell Metabolism·Calvin S CarterVal C Sheffield

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Methods Mentioned

BETA
light microscopy
MDA

Software Mentioned

STATISTICA

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