Tempol treatment reduces anxiety-like behaviors induced by multiple anxiogenic drugs in rats

PloS One
Gaurav PatkiSamina Salim

Abstract

We have published that pharmacological induction of oxidative stress (OS) causes anxiety-like behavior in rats. Using animal models, we also have established that psychological stress induces OS and leads to anxiety-like behaviors. All evidence points towards the causal role of OS in anxiety-like behaviors. To fully ascertain the role of OS in anxiety-like behaviors, it is reasonable to test whether the pro-anxiety effects of anxiogenic drugs caffeine or N-methyl-beta-carboline-3-carboxamide (FG-7142) can be mitigated using agents that minimize OS. In this study, osmotic pumps were either filled with antioxidant tempol or saline. The pumps were attached to the catheter leading to the brain cannula and inserted into the subcutaneous pocket in the back pocket of the rat. Continuous i.c.v. infusion of saline or tempol in the lateral ventricle of the brain (4.3 mmol/day) was maintained for 1 week. Rats were intraperitoneally injected either with saline or an anxiogenic drug one at a time. Two hours later all groups were subjected to behavioral assessments. Anxiety-like behavior tests (open-field, light-dark and elevated plus maze) suggested that tempol prevented anxiogenic drug-induced anxiety-like behavior in rats. Furthermore, an...Continue Reading

References

Jan 26, 1978·The New England Journal of Medicine·D RobertsonJ A Oates
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·H A Baldwin, S E File
Jan 10, 1989·European Journal of Pharmacology·H A BaldwinS E File
Jan 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·S E File, S Pellow
Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
Jan 1, 1997·Journal of Psychopharmacology·S K BhattacharyaA Chakrabarti
Dec 5, 1998·Neurochemistry International·K J Kovács
Jul 2, 1999·Methods and Findings in Experimental and Clinical Pharmacology·T SkrebuhhovaV Matto
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·A J Oliveira-Dos-SantosJ M Penninger
Jun 20, 2002·Neurobiology of Learning and Memory·Bettina BertMechthild Voits
Sep 12, 2002·Pharmacological Reviews·Susanne Hollinger, John R Hepler
Oct 3, 2002·American Journal of Respiratory Cell and Molecular Biology·Marie-Christine NlendMatthias Salathe
Jan 14, 2003·Seminars in Cell & Developmental Biology·Jonathan Flint
Feb 27, 2003·The Journal of Biological Chemistry·Samina SalimCarmen W Dessauer
Sep 22, 2005·Journal of Clinical Periodontology·Rosanna Di PaolaSalvatore Cuzzocrea
Jul 6, 2006·Cellular Signalling·Kyun HeoPann-Ghill Suh
Aug 31, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Huxing CuiOsamu Shirakawa
Jan 22, 2008·The International Journal of Neuropsychopharmacology·Felicity NgAshley I Bush
Mar 5, 2008·Archives of General Psychiatry·Jordan W SmollerMurray B Stein
May 9, 2009·The Journal of Nutritional Biochemistry·Kyuichi KawabataJunji Terao
Sep 12, 2009·European Journal of Pharmacology·Nagaraja HaleagraharaPonnusamy Kumar
Jan 13, 2010·Behavioural Brain Research·Samina SalimGaurav Chugh
Jul 22, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Matthew W HaleChristopher A Lowry
May 20, 2011·American Journal of Physiology. Renal Physiology·Anees Ahmad Banday, Mustafa F Lokhandwala
Mar 31, 2012·Brain Research·Naoki OkimotoKazuhito Tomizawa
Jul 21, 2012·Advances in Protein Chemistry and Structural Biology·Samina SalimMohammad Asghar
Aug 24, 2012·Behavioral and Brain Functions : BBF·Akeo Kurumaji, Toru Nishikawa
Aug 28, 2012·Biochemical and Biophysical Research Communications·Chau H NguyenPeter Chidiac
Apr 1, 2009·Indian Journal of Clinical Biochemistry : IJCB·Sutirtha ChakrabortyNikhiles Mandal
Apr 25, 2013·Translational Psychiatry·N VogelzangsB W J H Penninx
Mar 4, 2014·BioMed Research International·Anu RahalKuldeep Dhama

❮ Previous
Next ❯

Citations

May 30, 2015·Nutrition Research·Gaurav PatkiSamina Salim
Dec 13, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ridha Ben AliMichèle Véronique El May
May 11, 2018·Free Radical Research·Alessandra das Graças FedoceKelvin J A Davies
Oct 28, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hesong LiuSamina Salim

❮ Previous
Next ❯

Methods Mentioned

BETA
Dissections
electrophoresis
ELISA
GTPase

Software Mentioned

GraphPad

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.