Temporal analysis of invasive pneumococcal clones from Scotland illustrates fluctuations in diversity of serotype and genotype in the absence of pneumococcal conjugate vaccine.

Journal of Clinical Microbiology
Johanna M JefferiesS C Clarke

Abstract

In September 2006, the seven-valent pneumococcal conjugate vaccine (PCV7; Prevenar) was introduced into the childhood vaccination schedule in the United Kingdom. We monitored the population of invasive pneumococci in Scotland in the 5 years preceding the introduction of PCV7 by using serogrouping, multilocus sequence typing (MLST), and eBURST analysis. Here, we present a unique analysis of a complete national data set of invasive pneumococci over this time. We observed an increase in invasive pneumococcal disease (IPD) caused by serotypes 1, 4, and 6 and a decrease in serogroup 14-, 19-, and 23-associated disease. Analysis of sequence type (ST) data shows a significant increase in ST306, associated with serotype 1, and a decrease in ST124, associated with serotype 14. There have also been increases in the amounts of IPD caused by ST227 (serotype 1) and ST53 (serotype 8), although these increases were not found to reach significance (P = 0.08 and 0.06, respectively). In the course of the study period preceding the introduction of PCV7, we observed considerable and significant changes in serogroup and clonal distribution over time.

References

Mar 1, 1993·The Medical Journal of Australia·M GrattenI Riley
Feb 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R DaganP Yagupsky
Feb 15, 2001·Current Opinion in Pediatrics·M Ledwith
Sep 11, 2001·The Journal of Infectious Diseases·B Henriques NormarkG Källenius
Oct 30, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Moe H KyawHarry Campbell
Feb 21, 2004·The Journal of Infectious Diseases·A SandgrenB Henriques Normark
Dec 25, 2004·Infection and Immunity·William P HanageBrian G Spratt
Aug 10, 2005·The Journal of Infectious Diseases·Andreas SandgrenBirgitta Henriques-Normark
Jan 5, 2006·Journal of Clinical Microbiology·Lea-Ann S KirkhamTim J Mitchell
Jan 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K SjöströmB Henriques-Normark
Mar 7, 2006·Journal of Clinical Microbiology·Bernard BeallUNKNOWN Active Bacterial Core Surveillance Team
Apr 25, 2006·Molecular Biotechnology·C B SullivanS C Clarke
May 30, 2006·The Pediatric Infectious Disease Journal·Margaret FletcherUNKNOWN South West of England Invasive Community Acquired Infection Study Group
Feb 3, 2007·Journal of Clinical Microbiology·In Ho ParkMoon H Nahm
Jul 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·K SjöströmB Henriques-Normark
Aug 19, 2007·The Journal of Infectious Diseases·Johanna M C JefferiesTim J Mitchell
Sep 15, 2007·FEMS Immunology and Medical Microbiology·Ricardo Dias, Manuela Caniça
Feb 14, 2008·The Journal of Infectious Diseases·Monica MoschioniMichèle A Barocchi
Oct 17, 2008·Nature Reviews. Microbiology·Birgitta Henriques-NormarkStaffan Normark
Oct 31, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael R JacobsAnne R Windau
Nov 6, 2008·The Journal of Infectious Diseases·In H ParkUNKNOWN Active Bacterial Core Surveillance Team
Jan 2, 2009·BMJ : British Medical Journal·Atul GuptaD A Spencer
Jan 7, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Anke HussMatthias Egger

❮ Previous
Next ❯

Citations

Mar 14, 2013·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Naoko ChibaUNKNOWN Invasive Pneumococcal Diseases Surveillance Study Group
Dec 24, 2011·Future Microbiology·Neil D RitchieTom J Evans
Jan 27, 2016·Emerging Infectious Diseases·Claire von MollendorfUNKNOWN Group for Enteric, Respiratory, and Meningeal Disease Surveillance in South Africa (GERMS-SA)
Oct 23, 2010·Journal of Medical Microbiology·R A GladstoneS C Clarke
Feb 19, 2011·Journal of Medical Microbiology·J M C JefferiesS C Clarke
Apr 2, 2015·Wiener klinische Wochenschrift·Manica Müller PremruVesna Cvitković Špik
Jul 17, 2015·PLoS Pathogens·Eleanor R WatkinsSunetra Gupta
Aug 8, 2017·Expert Review of Vaccines·Raul IsturizLuis Jodar
Aug 5, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Rebecca A GladstoneMartin J Holland
Feb 15, 2012·Vaccine·Jae-Hoon SongBernard Fritzell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.