Temporal and spatial action of tolloid (mini fin) and chordin to pattern tail tissues

Developmental Biology
S A ConnorsMary C Mullins

Abstract

In vertebrates, a bone morphogenetic protein (BMP) signaling pathway patterns all ventral cell fates along the embryonic axis. BMP activity is positively regulated by Tolloid, a metalloprotease, that can eliminate the activity of the BMP antagonist Chordin. A tolloid mutant in zebrafish, mini fin (mfn), exhibits a specific loss of ventral tail tissues. Here, we investigate the spatial and temporal requirements for Tolloid (Mfn) in dorsoventral patterning of the tail. Through chimeric analyses, we found that Tolloid (Mfn) functions cell non-autonomously in the ventral-most vegetal cells of the gastrula or their derivatives. We generated a tolloid transgene under the control of the inducible hsp70 promoter and demonstrate that tolloid (mfn) is first required at the completion of gastrulation. Although tolloid is expressed during gastrulation and dorsally and ventrally within the tail bud, our results indicate that Tolloid (Mfn) acts specifically in the ventral tail bud during a approximately 4 h period extending from the completion of gastrulation to early somitogenesis stages to regulate BMP signaling. Examination of the temporal requirements of Chordin activity by overexpression of the hsp70-tolloid transgene indicates that Cho...Continue Reading

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Citations

Sep 29, 2011·Annual Review of Genetics·Yvette G Langdon, Mary C Mullins
Jun 20, 2012·FEBS Letters·Marie-Christine Ramel, Caroline S Hill
Jul 1, 2015·Seminars in Cell & Developmental Biology·Francesca B Tuazon, Mary C Mullins
Aug 2, 2011·Developmental Biology·Mollie R Johnson Sorrell, Joshua S Waxman
Aug 31, 2007·Developmental Biology·Heather L StickneyWilliam S Talbot
Jun 11, 2017·Cold Spring Harbor Perspectives in Biology·Joseph ZinskiMary C Mullins
Oct 25, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Shawn C Little, Mary C Mullins
Jul 15, 2016·Cold Spring Harbor Perspectives in Biology·Chenbei Chang

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