Temporal and Spatial Changes of μ-Opioid Receptors in the Brain, Spinal Cord and Dorsal Root Ganglion in a Rat Lumbar Disc Herniation Model

Spine
Yoichi KaneuchiShin-Ichi Konno

Abstract

Controlled, interventional, animal study. To investigate the spatial and temporal changes of μ-opioid receptor (MOR) expression in a rat lumbar disc herniation (LDH) model. MORs widely express in the peripheral and central nervous systems, and opioid drugs produce an analgesic effect through their activation. However, the efficacy of opioid drugs is sometimes inadequate in several pathological conditions of pain. MORs in the brain as well as the spinal cord (SC) and dorsal root ganglion (DRG) are thought to be associated with pain-related behavior, but the underlying mechanisms are not completely understood. In all, 91 adult female Sprague-Dawley rats were used. Autologous nucleus pulposus (NP) was applied onto the left L5 DRG in the NP group rats. Rats were divided into two surgical groups, the NP and the sham group. The von Frey test of left hind paw was performed before surgery, and 2, 7, 14, 21 and 28 days after surgery. Immunohistochemistry and immunoblotting in the DRG, SC, Caudate putamen, nucleus accumbens (NAc) and periaqueductal grey matter were performed before surgery, and 2, 7, 14, 21 and 28 days after surgery. The thresholds in the NP group were significantly lower than those in the sham group from day 2 onwards. ...Continue Reading

References

Apr 1, 1981·Pain·Albert J Tahmoush
Jan 1, 1995·Pain·E H Chudler, W K Dong
Apr 1, 1993·British Journal of Pharmacology·L C Stanfa, A H Dickenson
Aug 1, 1997·Brain Research·R E CoggeshallS M Carlton
Jan 13, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M KawakamiT Tamaki
Dec 16, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H BrisbyB Rydevik
Aug 7, 2002·Spine·Yoshihito AokiKjell Olmarker
Feb 26, 2003·Annals of Neurology·Wayne TruongDouglas W Zochodne
Jan 14, 2004·The Journal of Pharmacology and Experimental Therapeutics·Md Harunor RashidHiroshi Ueda
Jun 23, 2004·Nature Reviews. Neuroscience·Howard Fields
Oct 7, 2004·European Journal of Pharmacology·Nora HagelbergAntti Pertovaara
Jul 22, 2005·Experimental Brain Research·O CiccarelliA J Thompson
Jan 24, 2006·Pain·Patrick B Wood
Mar 21, 2006·Life Sciences·Andrew C GrayPaul J White
Sep 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Richard E HarrisJon-Kar Zubieta
Apr 5, 2011·Experimental Neurology·Robert W Gear, Jon D Levine
May 21, 2011·European Journal of Pain : EJP·Keiko K LeeHiroyuki Kobayashi
Sep 11, 2012·The Open Orthopaedics Journal·Priscilla Y HwangLori A Setton
Jun 6, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Hiroharu SaitoShinichi Konno

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Citations

Oct 23, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ryohei SatoShin-Ichi Konno
Jul 24, 2020·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Shota YomogidaShin-Ichi Konno

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