Temporal and spatial expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases following myocardial infarction.

Cardiovascular Therapeutics
Merry L Lindsey, Rogelio Zamilpa

Abstract

Following a myocardial infarction (MI), the homeostatic balance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) is disrupted as part of the left ventricle (LV) response to injury. The full complement of responses to MI has been termed LV remodeling and includes changes in LV size, shape and function. The following events encompass the LV response to MI: (1) inflammation and LV wall thinning and dilation, (2) infarct expansion and necrotic myocyte resorption, (3) accumulation of fibroblasts and scar formation, and (4) endothelial cell activation and neovascularization. In this review, we will summarize MMP and TIMP roles during these events, focusing on the spatiotemporal localization and MMP and TIMP effects on cellular and tissue-level responses. We will review MMP and TIMP structure and function, and discuss specific MMP roles during both the acute and chronic phases post-MI, which may provide insight into novel therapeutic targets to limit adverse remodeling in the MI setting.

References

Jun 1, 1995·Journal of Molecular and Cellular Cardiology·J P CleutjensK T Weber
Oct 1, 1995·Journal of Molecular and Cellular Cardiology·S C TyagiW Fortson
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·E LeviI Vlodavsky
Nov 29, 1996·The Journal of Biological Chemistry·J GreeneY E Shi
Jul 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S M AlexanderP G McGuire
Nov 5, 1997·European Journal of Biochemistry·V KnäuperG Murphy
Aug 26, 1998·Journal of Molecular and Cellular Cardiology·C C DanielsenH R Andersen
Jul 6, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M CorbelV Lagente
Aug 3, 2000·American Journal of Physiology. Heart and Circulatory Physiology·L LuG G Schwartz
May 31, 2001·The Journal of Cell Biology·M KajitaM Seiki
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·M L CokerF G Spinale
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T EtohF G Spinale
Sep 28, 2001·Trends in Immunology·G OpdenakkerJ Van Damme
Feb 20, 2002·Journal of Molecular and Cellular Cardiology·Ute SeelandMichael Böhm
Mar 23, 2002·Circulation Research·Francis G Spinale
May 7, 2002·Nature Reviews. Cancer·Mikala Egeblad, Zena Werb
Jun 14, 2002·Basic Research in Cardiology·Anna Ratajska, Jack P M Cleutjens
Sep 28, 2002·Journal of Dental Research·M TsubotaH Shimauchi
Dec 14, 2002·Circulation Research·Toshihiro TsurudaJohn C Burnett
Apr 8, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Hongjiang ChenJawahar L Mehta

❮ Previous
Next ❯

Citations

Aug 29, 2012·Journal of Cardiovascular Translational Research·Yonggang MaMerry L Lindsey
Jan 1, 1991·Molecular Aspects of Medicine·D L ScottD R Blake
Nov 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·P LegendreJ J Reynolds
Aug 21, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Rugmani Padmanabhan IyerMerry L Lindsey
Feb 8, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Rogelio ZamilpaMerry L Lindsey
Jan 21, 2012·Circulation·Kristine Y DeleonMerry L Lindsey
Jun 5, 2013·Fibrogenesis & Tissue Repair·Yonggang MaMerry L Lindsey
Dec 4, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Margaret W NdinguriGregg B Fields
May 2, 2014·Biochemical Pharmacology·Francis G Spinale, Francisco Villarreal
Feb 13, 2014·Pflügers Archiv : European journal of physiology·Yonggang MaMerry L Lindsey
Jul 6, 2014·Basic Research in Cardiology·Bryan G Hughes, Richard Schulz
Sep 30, 2014·Prostaglandins & Other Lipid Mediators·Kamal M KassemPamela Harding
Sep 28, 2014·Journal of Molecular and Cellular Cardiology·Ashley DeCouxRichard Schulz
Jul 23, 2015·Proteomics. Clinical Applications·Chia Wei ChangLeigh G Griffiths
Jan 8, 2016·Journal of Molecular and Cellular Cardiology·Samantha D Francis StuartCrystal M Ripplinger
Jan 2, 2016·Journal of Molecular and Cellular Cardiology·Merry L LindseyYonggang Ma
Dec 3, 2014·Pharmacology & Therapeutics·Chengxue QinRebecca H Ritchie
Dec 11, 2013·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Toshio KinoshitaYoshikiyo Akasaka
Sep 15, 2012·Journal of Molecular and Cellular Cardiology·Matthias Nahrendorf
Aug 14, 2012·Vascular Pharmacology·Frans A van Nieuwenhoven, Neil A Turner
Aug 12, 2015·Cardiovascular Research·José González-SantamaríaFernando Rodríguez-Pascual
Nov 27, 2015·Journal of Molecular and Cellular Cardiology·Angela C ZeiglerJeffrey J Saucerman
Mar 28, 2013·Proteomics. Clinical Applications·Nicolle L PattersonMerry L Lindsey
Mar 25, 2016·Heart Failure Reviews·Alessandro PingitoreFrancesca Forini
Jul 16, 2015·Expert Review of Proteomics·Sabrina Amar, Gregg B Fields
Jan 18, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Gregg B Fields
Mar 24, 2015·International Journal of Cardiology·Rugmani Padmanabhan IyerMerry L Lindsey
Nov 9, 2016·International Journal of Cardiology·Tarek A Abd El-Aziz, Rasha H Mohamed
Apr 6, 2017·Journal of Cellular and Molecular Medicine·Elena Revuelta-LópezVicenta Llorente-Cortés
Feb 23, 2017·Revista da Associação Médica Brasileira·Aldenora Oliveira do Nascimento HolandaDilina do Nascimento Marreiro
Sep 8, 2017·Advanced Healthcare Materials·Logan J WorkeCorey P Neu
Oct 29, 2014·Organic & Biomolecular Chemistry·José María ZapicoAna Ramos
May 22, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Rugmani Padmanabhan IyerMerry L Lindsey
Jul 30, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Shayne C BarlowFrancis G Spinale
Jun 12, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Laura L DanielKrishna Singh
Oct 23, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Shigemiki OmiyaKinya Otsu
Jan 13, 2018·Journal of Cellular Physiology·Peramaiyan RajendranChih-Yang Huang
Mar 31, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Alan J MoutonMerry L Lindsey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

© 2021 Meta ULC. All rights reserved