Temporal and spatial expression of TGF-beta1 in an Achilles tendon section model after application of platelet-rich plasma

Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons
Dimitrios N LyrasDionysios Verettas

Abstract

To investigate the effect of platelet-rich plasma (PRP) on TGF-beta1 expression during tendon healing. We used 48 skeletally mature New Zealand White rabbits. 24 rabbits received the PRP, and 24 rabbits served as an untreated control group. Equal numbers of animals were sacrificed at 1st, 2nd, 3rd, and 4th week. The surgical procedure involved a transverse incision to transect the Achilles tendon. A volume of 1ml of PRP was then injected into the tendon mass in the PRP group. Histological and immunohistochemical evaluations with an anti-TGF-beta primary antibody were performed. The pattern of expression of TGF-beta1 in the PRP group was characterized by a significant upregulation during the first 2 weeks and subsequently significant downregulation in the 3rd and 4th week in comparison with the controls. Our results suggest that PRP may affect the tendon healing process by altering the expression of TGF-beta1.

References

Jun 1, 1993·American Journal of Surgery·N T Bennett, G S Schultz
Nov 26, 1997·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·D H WhitmanD M Green
Jan 13, 2000·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·G M SaedM P Diamond
May 10, 2003·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Emmanuel SofferFani Anagnostou
May 23, 2003·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Hwan T HeeLeann Myers
Mar 17, 2004·Acta Orthopaedica Scandinavica·Per Aspenberg, Olena Virchenko
Sep 21, 2005·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Shuji YamazakiAkio Minami
Mar 24, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Martha M MurrayDavid Zurakowski
Oct 13, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Martha M MurraySusan A Connolly
Jul 28, 2007·The Journal of Surgical Research·Kyriakos ZafirellisChristos Kombouras
Jan 9, 2008·Journal of Cellular Physiology·Yoshiteru KajikawaToshikazu Kubo
May 13, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Kai-Ming ChanMargaret Wan-Nar Wong
Apr 28, 2009·British Medical Bulletin·Anil KhannaNicola Maffulli

❮ Previous
Next ❯

Citations

Oct 14, 2011·Current Osteoporosis Reports·Jameel IqbalEllen Klapper
Aug 9, 2011·Sports Medicine and Arthroscopy Review·Omer Mei-Dan, Michael R Carmont
Apr 25, 2013·Veterinary and Comparative Orthopaedics and Traumatology : V.C.O.T·R F SilvaC M F Rezende
Jan 29, 2013·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Nikolas BakshJohn G Kennedy
Jan 31, 2012·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Stacie G BoswellLisa A Fortier
Aug 14, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Patrick SadoghiPatrick Vavken
Jun 1, 2012·Platelets·J AlsousouP Harrison
Feb 12, 2014·Platelets·Laís Fernanda MarquesJoão Tadeu Ribeiro-Paes
Dec 3, 2014·Physical Medicine and Rehabilitation Clinics of North America·Ken Mautner, Lee Kneer
Dec 29, 2016·Acta orthopaedica et traumatologica turcica·Masaki TakamuraMasashi Neo
Feb 8, 2013·The Journal of Bone and Joint Surgery. American Volume·J Andrés Fernández-SarmientoRamón Cugat

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved