PMID: 9429098Jan 16, 1998Paper

Temporal and spatial patterns of osteoblast activation following implantation of beta-TCP particles into bone

Journal of Biomedical Materials Research
M NeoU Gross

Abstract

Temporal and spatial patterns of osteoblast activation around beta-TCP particles implanted into bone were analyzed by in situ hybridization with digoxygenin-labeled procollagen alpha 1(I) RNA probes. beta-TCP particles (150-300 microns in diameter) were implanted into rat tibiae, and specimens were collected 3, 5, 7, 14, and 28 days after operation. Activated osteoblasts displayed intense procollagen alpha 1(I) RNA specific labeling. At day 3, osteoblasts lining pre-existing trabeculae in places showed a specific signal. Additionally, scattered activated cells compatible with preosteoblasts also were observed in the vicinity of the trabeculae among red blood cells that filled the space between beta-TCP particles. Osteoblast activation on the surface of beta-TCP rarely was observed. At days 5 and 7, osteoblast activation and bone formation advanced centripetally. At the forefront of bone formation positive cells were scattered in the blood cell clots, and some of the positive cells colonized forming new bone matrix. Formation of new bone did not always begin at the surface of beta-TCP. At day 14, most of the beta-TCP particles were tightly associated with newly formed bone, and the number of positive osteoblasts was reduced. At ...Continue Reading

References

Oct 1, 1991·Journal of Biomedical Materials Research·S KotaniT Kokubo
Sep 1, 1983·Journal of Biomedical Materials Research·C P KleinA van den Hooff
Sep 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H ZhouK W Ng
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Apr 1, 1996·Journal of Biomedical Materials Research·M NeoU M Gross

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Citations

Sep 28, 2000·Journal of Biomedical Materials Research·K OhsawaT Nakamura
Sep 25, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·L Le GuehennecP Layrolle
Feb 25, 2009·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Chao ShenLi-Yang Dai
Dec 26, 2007·Journal of Materials Science. Materials in Medicine·Guangpeng LiuYilin Cao
Apr 2, 2002·Biomaterials·Jörg HandschelUlrich Joos
Jul 28, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J WardH H Malluche
Jun 9, 2006·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·C KnabeM Stiller
Aug 25, 2011·Journal of Biomaterials Applications·A Kadow-RomackerB Wildemann
Oct 8, 2014·Plastic and Reconstructive Surgery. Global Open·Azusa ShimizuHiroshi Mizuno
Aug 19, 2018·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Yasuaki TohmaYasuhito Tanaka
Mar 24, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yasuhiro TanimotoKimiya Nemoto

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