Temporal and spatial resolution in transmission Raman spectroscopy

Applied Spectroscopy
Neil EverallI P Clark

Abstract

Picosecond time-resolved transmission Raman data were acquired for 1 mm thick powder samples of trans-stilbene, and a Monte Carlo model was developed that can successfully model the laser and Raman pulse profiles. Photon migration broadened the incident (approximately 1 ps) probe pulse by two orders of magnitude. As expected from previous studies of Raman photon migration in backscattering mode, the transmitted Raman pulse was broader than the transmitted laser pulse and took longer to propagate through the sample. The late-arriving photons followed tortuous flight paths in excess of 50 mm on traversing the 1 mm sample. The Monte Carlo code was also used to study the spatial resolution (lateral and depth) of steady-state transmission Raman spectroscopy in the diffusion regime by examining the distribution of Raman generation positions as a function of incident beam size, sample thickness, and transport length. It was predicted that the lateral resolution should worsen linearly with sample thickness (typically the resolution was about 50% of the sample thickness), and this is an inevitable consequence of operating in the diffusion regime. The lateral resolution was better at the sample surface (essentially determined by the prob...Continue Reading

References

Jan 1, 1996·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·J A MoonJ Reintjes
May 29, 2004·Applied Spectroscopy·Neil EverallMichael Towrie
Apr 26, 2005·Journal of Biomedical Optics·Michael D MorrisEdward R C Draper
Oct 20, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Edward R C DraperAllen E Goodship
Jan 11, 2007·Journal of Biomedical Optics·Matthew V SchulmerichSteven A Goldstein
Jan 16, 2007·Applied Spectroscopy·P Matousek, A W Parker
Jul 11, 2007·Chemical Society Reviews·Pavel Matousek
Aug 25, 2007·Applied Spectroscopy·P Matousek
Sep 21, 2007·Analytical Chemistry·C EliassonP Matousek
Oct 26, 2007·Applied Spectroscopy·C EliassonP Matousek
Feb 26, 2008·Journal of Pharmaceutical and Biomedical Analysis·Charlotte EliassonPavel Matousek
Apr 17, 2008·Pharmaceutical Research·Neil A Macleod, Pavel Matousek
Aug 6, 2008·Optics Express·Subhadra SrinivasanSteven A Goldstein
Nov 15, 2008·Applied Spectroscopy·Neil A Macleod, Pavel Matousek

❮ Previous
Next ❯

Citations

Feb 12, 2013·Analytical and Bioanalytical Chemistry·Dieter OelkrugRudolf W Kessler
Dec 22, 2014·Journal of Pharmaceutical and Biomedical Analysis·Laura C Mecker-Pogue, John F Kauffman
May 4, 2016·Analytical and Bioanalytical Chemistry·Dieter OelkrugKarsten Rebner
Jul 2, 2016·Applied Spectroscopy·K Alicia StrangeS Michael Angel
Mar 29, 2014·Applied Spectroscopy·Nicola KellichanGary McGeorge
Jun 12, 2010·Applied Spectroscopy·Matthew D KellerAnita Mahadevan-Jansen
Feb 11, 2015·The Analyst·Ingeborg E Iping PettersonFreek Ariese
Oct 4, 2012·Applied Spectroscopy·Alicia G Gonzálvez, Ángel González Ureña
Dec 14, 2011·Angewandte Chemie·Mathijs W ZandbergenAndrew M Beale
Dec 3, 2010·The Analyst·Kevin Buckley, Pavel Matousek
Jul 4, 2012·Journal of Agricultural and Food Chemistry·Matthew V SchulmerichRohit Bhargava
Oct 22, 2013·Analytical Chemistry·Matthew V SchulmerichRohit Bhargava

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.