Temporal and spatial variations of wall shear stress in the entrance region of microvessels

Journal of Biomechanical Engineering
Othmane Oulaid, Junfeng Zhang

Abstract

Using a simplified two-dimensional divider-channel setup, we simulate the development process of red blood cell (RBC) flows in the entrance region of microvessels to study the wall shear stress (WSS) behaviors. Significant temporal and spatial variation in WSS is noticed. The maximum WSS magnitude and the strongest variation are observed at the channel inlet due to the close cell-wall contact. From the channel inlet, both the mean WSS and variation magnitude decrease, with a abrupt drop in the close vicinity near the inlet and then a slow relaxation over a relatively long distance; and a relative stable state with approximately constant mean and variation is established when the flow is well developed. The correlations between the WSS variation features and the cell free layer (CFL) structure are explored, and the effects of several hemodynamic parameters on the WSS variation are examined. In spite of the model limitations, the qualitative information revealed in this study could be useful for better understanding relevant processes and phenomena in the microcirculation.

References

Jul 1, 1989·Microvascular Research·A R PriesP Gaehtgens
Oct 1, 1972·Microvascular Research·E Evans, Y C Fung
Aug 27, 1998·Hypertension·S Lehoux, A Tedgui
Nov 5, 2002·Biophysical Journal·Björn Neu, Herbert J Meiselman
May 7, 2003·Progress in Biophysics and Molecular Biology·Nitzan ResnickEfrat Wofovitz
Jan 13, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Heather A HimburgMorton H Friedman
Apr 5, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Herbert H Lipowsky
Mar 1, 2006·Journal of Biomechanical Engineering·Prosenjit BagchiAleksander S Popel
Feb 13, 2007·Biochemical and Biophysical Research Communications·Manolis Y PahakisJohn M Tarbell
Sep 25, 2007·Journal of Biomechanics·Junfeng ZhangAleksander S Popel
Jul 26, 2008·Annals of Biomedical Engineering·Michael P SzymanskiJohn Kolega
Aug 8, 2008·Annals of Biomedical Engineering·Jared O BarberTimothy W Secomb
Oct 6, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Joji Ando, Kimiko Yamamoto
Mar 31, 2010·Annals of Biomedical Engineering·Wenjuan Xiong, Junfeng Zhang
Jan 1, 2005·Annual Review of Fluid Mechanics·Aleksander S Popel, Paul C Johnson
Jun 1, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Junfeng Zhang
Aug 6, 2011·Biomechanics and Modeling in Mechanobiology·W W YanB M Fu
Jul 28, 2012·Biorheology·Xuewen Yin, Junfeng Zhang
Jan 31, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Peng Kai Ong, Sangho Kim
Mar 5, 2013·PloS One·Joseph S UzarskiPeter S McFetridge
Feb 11, 2014·Biophysical Journal·Jonathan B Freund, Julien Vermot
Dec 8, 2014·Biomechanics and Modeling in Mechanobiology·Othmane Oulaid, Junfeng Zhang

❮ Previous
Next ❯

Citations

Mar 7, 2019·Biomechanics and Modeling in Mechanobiology·Brenna HoganAbdul I Barakat
Jun 24, 2021·Journal of the Royal Society, Interface·Qi ZhouMiguel O Bernabeu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.