Temporal assessment of pancreatic blood flow and perfusion following secretin stimulation using noninvasive MRI

Journal of Magnetic Resonance Imaging : JMRI
Eleanor F CoxJohn Simpson

Abstract

To dynamically quantify pancreatic perfusion and flow within the arteries supplying the pancreas in response to secretin stimulation. Twelve healthy male subjects were scanned at 1.5T with arterial spin labeling to measure tissue perfusion and phase contrast magnetic resonance imaging (MRI) to measure vessel flow. Superior mesenteric (SMA), gastroduodenal (GDA), common hepatic (HA), and splenic (SA) arterial flow and pancreatic perfusion were serially measured for 50 minutes following 1 IU/kg intravenous secretin. The significance of differences between timepoints was tested using a repeated measures one-way analysis of variance (ANOVA). Baseline blood flow (mean ± SEM or median [IQR]) for SMA, HA, SA, and GDA was 7.6 ± 1.3, 4.0 ± 0.5, 8.2 ± 0.8, and 0.9 (0.8-1.4) ml/s, respectively. Baseline pancreatic perfusion was 200 ± 25 ml/100g/min. Blood flow increased in the SMA (234%, P < 0.0001) and GDA (155%, P = 0.015) immediately after secretin injection. Reduced HA blood flow was observed after 10 minutes (P = 0.066) with no change in SA flow (P = 0.533). Increased pancreatic perfusion was maintained for 40 minutes after injection with a maximal increase at 5 minutes (16.8%, P = 0.025). Intravenous secretin resulted in significant...Continue Reading

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Citations

Aug 1, 2016·Journal of Hepatology·Naaventhan PalaniyappanGuruprasad Padur Aithal
Jan 6, 2018·European Radiology·Khoschy SchawkatJohannes T Heverhagen
Mar 25, 2016·World Journal of Transplantation·Uriel BarkaiPaul de Vos
Aug 15, 2019·Journal of Magnetic Resonance Imaging : JMRI·Manuel TasoDavid C Alsop
Sep 20, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Manuel TasoDavid C Alsop
Dec 12, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Fabio NeryDavid L Thomas

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