Temporal association between antibiotic use and resistance in Klebsiella pneumoniae at a tertiary care hospital

Antimicrobial Resistance and Infection Control
Sukhyun RyuByung Chul Chun

Abstract

β-Lactam/β-lactamase inhibitors (BLBLIs) were introduced into clinical practice as an alternative to carbapenems for treating multi-drug-resistant Klebsiella pneumoniae infections. However, little is known about the relationship between BLBLI treatment and antimicrobial resistance. In this study, we investigated the trends and the temporal association between antibiotic use and antimicrobial resistance in K. pneumoniae isolates obtained between 2012 and 2016. Data regarding quarterly consumption (total number of prescriptions per quarter) of all BLBLIs, all third-generation cephalosporins, and all fluoroquinolones at a tertiary care hospital were obtained from the Korean Health Insurance Review and Assessment Service. Susceptibility data (isolation rate of antibiotic resistance per quarter) were obtained from the existing database of the same tertiary hospital. Regression analysis was used to analyze annual trends and cross-correlations to assess the temporal association on a quarterly basis between antibiotic consumption and antibiotic resistance in K. pneumoniae. The rate of resistance to piperacillin/tazobactam in K. pneumoniae significantly increased over the study period (p < 0.01). The consumption of all BLBLIs was also f...Continue Reading

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Citations

Oct 28, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Mi Seon HanSang Hee Lee
Mar 12, 2020·Frontiers in Microbiology·Miklos FuziAkos Toth
May 9, 2021·Journal of the American Pharmacists Association : JAPhA·May A ShawkiNirmeen A Sabry

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Software Mentioned

R
R Foundation for Statistical

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