Temporal bone characterization and cochlear implant feasibility in the common marmoset (Callithrix jacchus).

Hearing Research
Luke A JohnsonXiaoqin Wang

Abstract

The marmoset (Callithrix jacchus) is a valuable non-human primate model for studying behavioral and neural mechanisms related to vocal communication. It is also well suited for investigating neural mechanisms related to cochlear implants. The purpose of this study was to characterize marmoset temporal bone anatomy and investigate the feasibility of implanting a multi-channel intracochlear electrode into the marmoset scala tympani. Micro computed tomography (microCT) was used to create high-resolution images of marmoset temporal bones. Cochlear fluid spaces, middle ear ossicles, semicircular canals and the surrounding temporal bone were reconstructed in three-dimensional space. Our results show that the marmoset cochlea is ∼16.5 mm in length and has ∼2.8 turns. The cross-sectional area of the scala tympani is greatest (∼0.8 mm(2)) at ∼1.75 mm from the base of the scala, reduces to ∼0.4 mm(2) at 5 mm from the base, and decreases at a constant rate for the remaining length. Interestingly, this length-area profile, when scaled 2.5 times, is similar to the scala tympani of the human cochlea. Given these dimensions, a compatible multi-channel implant electrode was identified. In a cadaveric specimen, this electrode was inserted ¾ tur...Continue Reading

References

Jun 1, 1990·The Journal of the Acoustical Society of America·D D Greenwood
Jul 1, 1986·The Annals of Otology, Rhinology, and Laryngology·T L Eby, J B Nadol
Jan 9, 1999·American Journal of Physical Anthropology·F Spoor, F Zonneveld
May 13, 1999·Acta Oto-laryngologica·W GstoettnerC Czerny
Sep 24, 1999·Hearing Research·J Wysocki
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·X Wang
Apr 4, 2002·Journal of Neurophysiology·Srikantan S NagarajanMichael M Merzenich
Mar 4, 2003·Journal of Neurophysiology·Steven J Eliades, Xiaoqin Wang
Dec 24, 2003·The Journal of Experimental Biology·Henrik BrummDietmar Todt
Feb 4, 2005·Cerebral Cortex·Steven J Eliades, Xiaoqin Wang
Jun 15, 2005·Hearing Research·Wei LuRobert K Shepherd
Aug 27, 2005·Nature·Daniel Bendor, Xiaoqin Wang
Oct 7, 2005·Journal of Neurophysiology·Christopher DiMattina, Xiaoqin Wang
Mar 11, 2006·The Journal of Comparative Neurology·Lisa A de la MotheTroy A Hackett
Sep 29, 2006·The Journal of the Acoustical Society of America·Ashley L PistorioXiaoqin Wang
Mar 10, 2007·Hearing Research·Xiaoqin Wang
Aug 31, 2007·Journal of Neuroscience Methods·Stephen J RebscherBen H Bonham
Nov 24, 2007·Journal of Human Evolution·Rolf Quam, Yoel Rak
Mar 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Srivatsun Sadagopan, Xiaoqin Wang
Feb 20, 2009·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Slavomir BiedronJustus Ilgner
Jul 15, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Cory T MillerXiaoqin Wang
Dec 8, 2009·Hearing Research·Sean J Slee, Eric D Young
Feb 12, 2010·Journal of Neurophysiology·Daniel Bendor, Xiaoqin Wang
May 12, 2010·Cerebral Cortex·Paul V Watkins, Dennis L Barbour
May 14, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul C Nelson, Eric D Young
Nov 4, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Stefan FlohrHorst Kierdorf
Feb 10, 2011·Hearing Research·Michael S Osmanski, Xiaoqin Wang
May 5, 2011·Hearing Research·Robert ShepherdAndrew Wise
May 27, 2011·Journal of Neurophysiology·Edward L BartlettXiaoqin Wang
Aug 3, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steven J Eliades, Xiaoqin Wang

❮ Previous
Next ❯

Citations

May 24, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael S OsmanskiXiaoqin Wang
Jan 21, 2015·Hearing Research·Marcus Jeschke, Tobias Moser
Jun 10, 2016·Journal of Neurophysiology·Julia KingRobert C Froemke
Jul 10, 2018·Annual Review of Neuroscience·Xiaoqin Wang
Feb 26, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Christopher R KaufmannMarlan R Hansen
Aug 8, 2013·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Mathieu MarxOlivier Deguine
Jun 28, 2019·Frontiers in Neuroanatomy·Sho KuriharaHirotaka James Okano
Dec 22, 2019·Current Opinion in Neurobiology·Erin GlennonRobert C Froemke
Apr 28, 2021·Proceedings of the National Academy of Sciences of the United States of America·Daniel KeppelerTobias Moser
Sep 22, 2021·Developmental Neurobiology·Makoto HosoyaKaoru Ogawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.