PMID: 6409065Aug 1, 1983Paper

Temporal bone findings in trisomy 13 with cyclopia

Archives of Otolaryngology
K TomodaR S Wilroy

Abstract

Temporal bone findings in a fetus with trisomy 13 syndrome and cyclopia may be histopathologically characterized by the dysplasia of bony and membranous labyrinth and of the nervous system. In the left ear, there was a shortened cochlea housing a malformed Corti's organ appearing as a ribbonlike structure, an unexpected canal running obliquely through the scala tympani, a peculiar shape of the utricular macula and posterior canal crista, and a delayed ossifying process in the otic capsule. The poor development of the structures in the seventh and eighth nerves and their ganglions was observed in both ears. The type of anomaly can be classified as Mondini or Mondini-Alexander. The several anomalies might involve the organs that begin to develop during the period from five to eight gestational weeks.

Citations

Feb 18, 2014·Brain & Development·Harvey B SarnatWeiming Yu
Aug 12, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Joachim SchmutzhardAnnelies Schrott-Fischer
Dec 20, 2007·The Laryngoscope·Hisaki FukushimaMichael M Paparella
Feb 27, 2010·American Journal of Medical Genetics. Part a·Rudolf GlueckertAndreas R Janecke
Feb 1, 1990·Teratology·M FujinagaJ Fitzsimmons
Aug 1, 1987·The Australian & New Zealand Journal of Obstetrics & Gynaecology·C Y HuangS Y Li
Jun 27, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Hisaki FukushimaMichael M Paparella
Jan 12, 2010·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Matthew J CarfraeBradley W Kesser

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