Temporal bone histopathology of furosemide ototoxicity

Laryngoscope Investigative Otolaryngology
Felipe Santos, Joseph B Nadol

Abstract

To describe the human temporal bone pathology in two patients who incurred furosemide induced ototoxicity. 1) A 46-year-old woman in acute liver and renal failure treated with high doses of furosemide for anasarca who developed a rapidly progressive severe-to-profound asymmetric sensorineural hearing loss. 2) A 65-year-old woman with undifferentiated small cell carcinoma of the lung who received intravenous furosemide 1 day prior to death for pulmonary edema. Removal of temporal bones, histologic processing, and light microscopy of temporal bones. Temporal bone histopathology and correlation with clinical and audiometric data. All three temporal bones demonstrated edema and cystic changes in the stria vascularis. In the first case the furosemide exposure was associated with hearing loss and the pathological changes were more extensive including cystic changes in the Hensen's cells, collapse of Reissner's membrane and the tectorial membrane and diffuse loss of inner and outer hair cells with only modest reduction in the spiral ganglion cell population. In the second case, without attributable hearing loss, there was only modest reduction in hair cell and spiral ganglion cell counts. Pathological changes were not observed in the ...Continue Reading

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Citations

Jun 21, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Reuven IshaiJoseph B Nadol
May 16, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Sameer A AlviHinrich Staecker

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Methods Mentioned

BETA
light microscopy
biopsy
electron microscopy
cochlear implant

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