Temporal bone involvement of IgG4-related disease: a rare condition misleading to petrous apicitis causing lateral rectus palsy

BMJ Case Reports
Sanathorn ChowsilpaKannika Roongrotwattanasiri

Abstract

IgG4-related disease (IgG4-RD) of temporal bone is rare and clinical manifestation mimics infection. A 19-year-old female presented with progressive left earache and intermittent left nasal obstruction. Then, she rapidly developed left lateral rectus palsy. The physical examination revealed mild redness of left tympanic membrane and a small nasal polyp from the left middle meatus. CT scan showed left petrous apicitis and enhancing sinonasal mucosa. Therefore, Gradenigo's syndrome was first considered. The empirical intravenous antibiotic was immediately prescribed and surgery was performed. The intraoperative pale soft tissue mass in middle ear and polyp in the left nasal cavity were sent for pathological examination and found positive immunohistochemical stains for IgG4 in plasma cells. Systemic corticosteroid, the first-line treatment, was started and her symptoms were finally recovery.

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Citations

Dec 17, 2020·Ear, Nose, & Throat Journal·Qinzhan RenXiuyong Ding
Nov 3, 2020·Case Reports in Infectious Diseases·Jacqueline HodgesBrian Wispelwey
Mar 23, 2021·World Neurosurgery·Samuel J ClerMichael R Chicoine

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