Temporal Changes in Pneumococcal Colonization in HIV-infected and HIV-uninfected Mother-Child Pairs Following Transitioning From 7-valent to 13-valent Pneumococcal Conjugate Vaccine, Soweto, South Africa

The Journal of Infectious Diseases
Susan A NzenzeS A Madhi

Abstract

We investigated the impact of infant pneumococcal conjugate vaccine (PCV) immunization on pneumococcal colonization among human immunodeficiency virus (HIV)-infected and HIV-uninfected mother-child pairs. Pneumococcal colonization was assessed in May 2010-February 2011 (period 1; 7-valent PCV era) and May 2012-April 2013 (period 2; 13-valent PCV era). Standard microbiological methods were used for pneumococcus isolation and serotyping. In children 0-12 years, PCV13-serotype colonization decreased from period 1 to period 2 among HIV-uninfected (adjusted odds ratio [OR], 0.32; 95% confidence interval [CI], .25-.40) and HIV-infected children (adjusted OR, 0.37; 95% CI, .28-.49), while there was an increase in nonvaccine serotype colonization. Decreases in PCV13-serotype colonization were observed in HIV-uninfected women (adjusted OR, 0.44; 95% CI, .23-.81), with a similar trend in HIV-infected women. HIV-infected compared to -uninfected women had higher prevalence of overall (20.5% vs 9.7% in period 1; 13.8% vs 9.7% in period 2) and PCV13-serotype colonization (8.7% vs 5.4% in period 1; 4.8% vs 2.0% in period 2), P < .04 for all observations. Targeted PCV vaccination of African infants in a setting with high HIV prevalence was ass...Continue Reading

References

Aug 5, 2000·The Pediatric Infectious Disease Journal·F P PolackR E Willoughby
Apr 13, 2006·JAMA : the Journal of the American Medical Association·Katherine A PoehlingWilliam Schaffner
Sep 26, 2006·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·David B BlossomRobert A Salata
Feb 13, 2007·Diagnostic Microbiology and Infectious Disease·Christiane NicolettiAnna S Levin
Mar 5, 2010·The New England Journal of Medicine·Neil FrenchCharles F Gilks
Jan 24, 2013·The Pediatric Infectious Disease Journal·Marta C NunesShabir A Madhi
Feb 12, 2013·Bulletin of the World Health Organization·Peter BarronAmeena Goga
Jun 5, 2014·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·S A MadhiN Ngcobo
Nov 12, 2014·The New England Journal of Medicine·Anne von GottbergUNKNOWN GERMS-SA Investigators

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Citations

Feb 26, 2016·Human Vaccines & Immunotherapeutics·William P Hausdorff, William P Hanage
Jan 27, 2017·Human Vaccines & Immunotherapeutics·Yadong A CuiPatricia Saddier
Feb 24, 2017·Expert Review of Respiratory Medicine·Charles FeldmanTheresa Rossouw
Mar 11, 2016·Journal of Clinical Microbiology·Mignon du PlessisAnne von Gottberg
Oct 8, 2019·Expert Review of Vaccines·Myint Tin Tin HtarLuis Jodar
May 17, 2019·Nature Communications·John A LeesDiederik van de Beek
Jun 26, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Effua UsufAnna Roca
May 14, 2016·The Pediatric Infectious Disease Journal·Lindsay R GrantKatherine L O'Brien
Jun 21, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·John Njuma LibweaArto A Palmu

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